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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msx1tm1Rem
targeted mutation 1, Robert Maxson
MGI:3769671
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Msx1tm1Rem/Msx1tm1Rem
Msx2tm1Yvla/Msx2tm1Yvla
Tg(Tek-cre)1Ywa/0 		involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI * SJL MGI:5297712
cn2
 		Msx1tm1Rem/Msx1tm1Rem
Msx2tm1Yvla/Msx2tm1Yvla
Taglntm2(cre)Yec/Tagln+ 		involves: 129S2/SvPas * 129S6/SvEvTac * NMRI MGI:5297710
cn3
 		Msx1tm1Rem/Msx1tm1Rem
Tg(Msx2-cre)5Rem/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3769673


Genotype
MGI:5297712
cn1
Allelic
Composition		 Msx1tm1Rem/Msx1tm1Rem
Msx2tm1Yvla/Msx2tm1Yvla
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rem mutation (1 available); any Msx1 mutation (19 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (26 available)
Tg(Tek-cre)1Ywa mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:173525 )
N
• carotid artery diamter and vascular smooth muscle cell (VSMC) are observed




Genotype
MGI:5297710
cn2
Allelic
Composition		 Msx1tm1Rem/Msx1tm1Rem
Msx2tm1Yvla/Msx2tm1Yvla
Taglntm2(cre)Yec/Tagln+
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rem mutation (1 available); any Msx1 mutation (19 available)
Msx2tm1Yvla mutation (0 available); any Msx2 mutation (26 available)
Taglntm2(cre)Yec mutation (1 available); any Tagln mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal carotid artery morphology ( J:173525 )
• increased carotid artery section surface (increased vessel diameter) is observed
vascular smooth muscle hypoplasia ( J:173525 )
• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

muscle
vascular smooth muscle hypoplasia ( J:173525 )
• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed




Genotype
MGI:3769673
cn3
Allelic
Composition		 Msx1tm1Rem/Msx1tm1Rem
Tg(Msx2-cre)5Rem/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rem mutation (1 available); any Msx1 mutation (19 available)
Tg(Msx2-cre)5Rem mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

digestive/alimentary system

growth/size/body
cleft palate ( J:128624 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory