Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^tm1(Wnt4)Bhr
• Allele Name: targeted mutation 1, Richard R Behringer
• Allele ID: MGI:3769474
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Wnt4)Bhr/Gt(ROSA)26Sor^+ Tg(Col2a1-cre)1Bhr/0	involves: 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3769501

Genotype
MGI:3769501

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm1(Wnt4)Bhr/Gt(ROSA)26Sor⁺; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth defects in Gt(ROSA)26Sor^tm1(Wnt4)Bhr/Gt(ROSA)26Sor⁺ Tg(Col2a1-cre)1Bhr/0 mice

cellular

decreased chondrocyte proliferation ( J:129327 )

• chondrocytes are proliferating 36% slower than controls at two weeks of age

growth/size/body

long incisors ( J:129327 )

• protruding incisors are observed in nine month old mice

short nasal bone ( J:129327 )

• nasal bones of six week old mice are significantly shortened

decreased body weight ( J:129327 )

• male mice are 50-60% of the bodyweight as age-matched controls

• female mice are 60-70% of the bodyweight as age-matched controls

disproportionate dwarf ( J:129327 )

• mice are undersized with shortened axial skeletons, altered head shape and disproportionately shorter limbs

skeleton

decreased chondrocyte proliferation ( J:129327 )

• chondrocytes are proliferating 36% slower than controls at two weeks of age

abnormal craniofacial bone morphology ( J:129327 )

small frontal bone ( J:129327 )

• frontal bones are slightly smaller

small occipital bone ( J:129327 )

• occipital are slightly smaller

long incisors ( J:129327 )

• protruding incisors are observed in nine month old mice

short nasal bone ( J:129327 )

• nasal bones of six week old mice are significantly shortened

domed cranium ( J:129327 )

• the skulls have a dome-shaped neurocranium vault

abnormal pubis morphology ( J:129327 )

• the pubic and ischial bones have failed to fuse at six weeks of age

• ossification of the bones occurs by 8 weeks of age but the pubic bone is still thinner

kyphosis ( J:129327 )

• is observed in nine-month old mice

short lumbar vertebrae ( J:129327 )

• vertebrae are narrow and flat caused by a reduction in lateral bone

axial skeleton hypoplasia ( J:129327 )

• axial skeletion is shortened compared to wild-type controls

abnormal bone marrow morphology ( J:129327 )

• the tibiae are deficient in bone marrow and are instead filled with adipocytes at 9 months of age

abnormal cartilage morphology ( J:129327 )

increased width of hypertrophic chondrocyte zone ( J:129327 )

• found in mice two weeks of age

disorganized long bone epiphyseal plate ( J:129327 )

• found in mice two weeks of age with less columnar organization

abnormal chondrocyte morphology ( J:129327 )

• less vascular endothelium growth factor is expressed by cells in the chondrocyte zones of the tibiae

delayed endochondral bone ossification ( J:129327 )

• primary ossification centers do not form in the tibiae until after E15.5

• formation of secondary ossification centers in the tibiae are delayed by four days

craniofacial

abnormal craniofacial bone morphology ( J:129327 )

small frontal bone ( J:129327 )

• frontal bones are slightly smaller

small occipital bone ( J:129327 )

• occipital are slightly smaller

long incisors ( J:129327 )

• protruding incisors are observed in nine month old mice

short nasal bone ( J:129327 )

• nasal bones of six week old mice are significantly shortened

domed cranium ( J:129327 )

• the skulls have a dome-shaped neurocranium vault

limbs/digits/tail

short limbs ( J:129327 )

• visibly shorter

behavior/neurological

decreased locomotor activity ( J:129327 )

• slow movement, which is possibly a result of the abnormal skeletal features

respiratory system

short nasal bone ( J:129327 )

• nasal bones of six week old mice are significantly shortened