Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat8tm2Thl mutation
(0 available);
any
Kat8 mutation
(36 available)
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mortality/aging
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• mice die prior to the onset of gastrulation and are all dead by E7.5
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embryo
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• by E7.5, deciduas contain only clusters of cells within a small sac or some giant cells only
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Allelic Composition |
Atmtm1Led/Atm+ Kat8tm2Thl/Kat8+
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Genetic Background |
involves: 129S1/Sv * 129S6/SvEvTac |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Led mutation
(0 available);
any
Atm mutation
(169 available)
Kat8tm2Thl mutation
(0 available);
any
Kat8 mutation
(36 available)
|
|
|
mortality/aging
|
• only 76% of mice survive the first year
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Led mutation
(0 available);
any
Atm mutation
(169 available)
Kat8tm2Thl mutation
(0 available);
any
Kat8 mutation
(36 available)
|
|
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mortality/aging
|
• mice die earlier than Atmtm1Led homozygotes
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growth/size/body
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• mice exhibit a modest reduction in weight compared to Atmtm1Led homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat8tm2Thl mutation
(0 available);
any
Kat8 mutation
(36 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
|
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mortality/aging
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• mice die earlier than Trp53tm1Brdhomozygotes
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