All Phenotypes Hp<tm1Alev> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hp^tm1Alev/Hp^tm1Alev	involves: 129 * C57BL/6	MGI:3838400
cx2	Apoe^tm1Unc/Apoe^tm1Unc Hp^tm1Alev/Hp^tm1Alev	involves: 129	MGI:3790694

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cholesterol efflux ( J:129061 )

• mutant mice with induced diabetes have less cholesterol efflux from injected foam cells than controls

• foam cells reduce cholesterol efflux by in response to diabetes in wild-type mice

• wild-type foam cells in mutant mice reduce cholesterol efflux by about twice as much in response to diabetes as when present in wild-type mice

homeostasis/metabolism

decreased cholesterol efflux ( J:129061 )

• mutant mice with induced diabetes have less cholesterol efflux from injected foam cells than controls

• foam cells reduce cholesterol efflux by in response to diabetes in wild-type mice

• wild-type foam cells in mutant mice reduce cholesterol efflux by about twice as much in response to diabetes as when present in wild-type mice

renal/urinary system

increased kidney weight ( J:146516 )

• in mice with induced diabetes, mutant kidneys weigh more than diabetic controls (15.5 g/kg vs. 11.9 g/kg in wild-type)

abnormal renal glomerulus morphology ( J:146516 )

• induced diabetes leads to an increased total glomerular area greater than what is found in diabetic controls

abnormal proximal convoluted tubule morphology ( J:146516 )

• induced diabetes leads to an increased proximal tubule area greater than what is found in diabetic controls

decreased creatinine clearance ( J:146516 )

• induced diabetes leads to an increased creatinine clearance time that is around twice that compared to diabetic controls

• vitamin E treatment lowers this clearance time

growth/size/body

increased kidney weight ( J:146516 )

• in mice with induced diabetes, mutant kidneys weigh more than diabetic controls (15.5 g/kg vs. 11.9 g/kg in wild-type)

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Hp^tm1Alev/Hp^tm1Alev
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (146 available)
Hp^tm1Alev mutation (0 available); any Hp mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:134942 )

• iron deposition in atherosclerotic lesions is almost two times greater than what is observed in mice that are homozygotes for just the Apoe^tm1Unc allele

• there is also increased amounts of oxidized lipids and proteins occurring in the plaques

immune system

abnormal macrophage chemotaxis ( J:134942 )

• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoe^tm1Unc allele

cellular

abnormal macrophage chemotaxis ( J:134942 )

• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoe^tm1Unc allele

hematopoietic system

abnormal macrophage chemotaxis ( J:134942 )

• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoe^tm1Unc allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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