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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sirt5tm1Fwa
targeted mutation 1, Frederick W Alt
MGI:3769236
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sirt5tm1Fwa/Sirt5tm1Fwa involves: 129/Sv * 129S1/Sv MGI:3769239
cx2
 		Sirt3tm1.2Auw/Sirt3tm1.2Auw
Sirt5tm1Fwa/Sirt5tm1Fwa 		involves: 129S1/Sv MGI:6383811
cx3
 		Sirt3tm1.2Auw/Sirt3+
Sirt5tm1Fwa/Sirt5tm1Fwa 		involves: 129S1/Sv MGI:6383812
cx4
 		Sirt3tm1.2Auw/Sirt3tm1.2Auw
Sirt5tm1Fwa/Sirt5+ 		involves: 129S1/Sv MGI:6383813


Genotype
MGI:3769239
hm1
Allelic
Composition		 Sirt5tm1Fwa/Sirt5tm1Fwa
Genetic
Background		 involves: 129/Sv * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt5tm1Fwa mutation (1 available); any Sirt5 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:129009 )
• mice are viable, fertile and grossly healthy until at least 18 months of age
• mice do not exhibit globally increased mitochondrial protein acetylation levels relative to wild-type controls




Genotype
MGI:6383811
cx2
Allelic
Composition		 Sirt3tm1.2Auw/Sirt3tm1.2Auw
Sirt5tm1Fwa/Sirt5tm1Fwa
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt3tm1.2Auw mutation (0 available); any Sirt3 mutation (30 available)
Sirt5tm1Fwa mutation (1 available); any Sirt5 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to injury ( J:265592 )
• intermediate vulnerability to light-induced retinal degeneration compared with double heterozygotes and homozygotes




Genotype
MGI:6383812
cx3
Allelic
Composition		 Sirt3tm1.2Auw/Sirt3+
Sirt5tm1Fwa/Sirt5tm1Fwa
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt3tm1.2Auw mutation (0 available); any Sirt3 mutation (30 available)
Sirt5tm1Fwa mutation (1 available); any Sirt5 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to injury ( J:265592 )
• more vulnerable to light-induced retinal degeneration than double heterozygotes




Genotype
MGI:6383813
cx4
Allelic
Composition		 Sirt3tm1.2Auw/Sirt3tm1.2Auw
Sirt5tm1Fwa/Sirt5+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt3tm1.2Auw mutation (0 available); any Sirt3 mutation (30 available)
Sirt5tm1Fwa mutation (1 available); any Sirt5 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to injury ( J:265592 )
• intermediate vulnerability to light-induced retinal degeneration compared with double heterozygotes and homozygotes




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory