All Phenotypes Pold1<tm2Loeb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pold1^tm2Loeb
targeted mutation 2, Lawrence A Loeb
MGI:3769034

Summary

2 genotypes

Allelic Composition	Pold1^tm2Loeb/Pold1^tm2Loeb
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1^tm2Loeb mutation (1 available); any Pold1 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• no embryos are detected at E8.5

Allelic Composition	Pold1^tm2Loeb/Pold1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1^tm2Loeb mutation (1 available); any Pold1 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:129046 )

• median lifespan is reduced to 18 months compared to 22 months for wild-type mice and Pold1^tm1Loeb heterozygotes

• maximum lifespan is reduced to 27 months compared to 30 months for wild-type mice

• mortality rates increase after 11 months of age

neoplasm

increased tumor incidence ( J:129046 )

• the hazard ratio for all tumor types is increased compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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