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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pold1tm1Loeb
targeted mutation 1, Lawrence A Loeb
MGI:3769033
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pold1tm1Loeb/Pold1tm1Loeb involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3769038
ht2
 		Pold1tm1Loeb/Pold1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3769039


Genotype
MGI:3769038
hm1
Allelic
Composition		 Pold1tm1Loeb/Pold1tm1Loeb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1tm1Loeb mutation (1 available); any Pold1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3769039
ht2
Allelic
Composition		 Pold1tm1Loeb/Pold1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1tm1Loeb mutation (1 available); any Pold1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:129046 )
• maximum lifespan is reduced to 27 months compared to 30 months for wild-type mice
• however, median lifespan is normal
• mortality rates increase after 11 months of age

cardiovascular system
cardiomyopathy ( J:129046 )
• mice exhibit a high incidence of cardiomyopathy than wild-type mice

muscle
cardiomyopathy ( J:129046 )
• mice exhibit a high incidence of cardiomyopathy than wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory