Phenotypes associated with this allele

• Allele Symbol: Mlycd^tm1Jish
• Allele Name: targeted mutation 1, Kou-ichi Jishage
• Allele ID: MGI:3769013
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlycd^tm1Jish/Mlycd^tm1Jish	B6.129S7-Mlycd^tm1Jish	MGI:3769020

Genotype
MGI:3769020

hm1

• Allelic Composition: Mlycd^tm1Jish/Mlycd^tm1Jish
• Genetic Background: B6.129S7-Mlycd^tm1Jish

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood circulation ( J:126455 )

• following reperfusion of an ischemic heart ex vivo, rate pressure product is increased (16+/-1.3 compared to 10+/-2.1 beats per minute mm Hg x10^-3 in wild-type mice), cardiac work is increased (5.7+/-0.6 compared to 2.3+/-0.8 ml per minute mm Hg x10^-2 in wild-type mice), aortic flow is increased (5.5+/-0.9 compared to 1.5+/-0.6 ml per minute in wild-type mice), and cardiac power is increased (61.4+/-6.9 compared to 25.2+/-9.1 mJ per minute in wild-type mice)

• recovery after cardiac ischemia is improved 2.5-fold compared to in wild-type mice and mice recover almost 80% of their preischemic values

increased cardiac output ( J:126455 )

• following reperfusion of an ischemic heart ex vivo, cardiac output is increased (9.4+/-0.9 ml per minute compared to 3.4+/-1.2 ml per minute in wild-type mice)

homeostasis/metabolism

abnormal glucose homeostasis ( J:126455 )

• following reperfusion of an ischemic heart ex vivo, glucose oxidation to produce ATP is increased 50% compared to in wild-type mice