All Phenotypes Herc4<Gt(RRH224)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Herc4^{Gt(RRH224)Byg}
gene trap RRH224, BayGenomics
MGI:3768764

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Herc4^{Gt(RRH224)Byg}/Herc4^{Gt(RRH224)Byg}	Not Specified	MGI:3768765

Allelic Composition	Herc4^{Gt(RRH224)Byg}/Herc4^{Gt(RRH224)Byg}
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Herc4^{Gt(RRH224)Byg} mutation (0 available); any Herc4 mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

kinked sperm flagellum ( J:128937 )

• mice exhibit a 3-fold higher number of sperm with marked angulation of the tails

asthenozoospermia ( J:128937 )

• spermatozoon forward motility is half that of wild-type counterparts

arrest of spermatogenesis ( J:128937 )

• cytoplasmic droplets are associated with angulations of the sperm tails, suggesting final maturation of the spermatozoa fails

reduced male fertility ( J:128937 )

• male mice sire litters that are half that in number compared to litters produced by wild-type males

cellular

kinked sperm flagellum ( J:128937 )

• mice exhibit a 3-fold higher number of sperm with marked angulation of the tails

asthenozoospermia ( J:128937 )

• spermatozoon forward motility is half that of wild-type counterparts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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