Phenotypes associated with this allele

• Allele Symbol: Chn1^tm1.1Abet
• Allele Name: targeted mutation 1.1, Andrea Betz
• Allele ID: MGI:3768535
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chn1^tm1.1Abet/Chn1^tm1.1Abet	involves: 129P2/OlaHsd * FVB/N	MGI:3768543

Genotype
MGI:3768543

hm1

• Allelic Composition: Chn1^tm1.1Abet/Chn1^tm1.1Abet
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

tonic seizures ( J:128724 )

abnormal axon extension ( J:128724 )

• fewer growth cones collapse in culture when neurons are treated with Efnb3 or Efna1 compared to in wild-type cultures

enlarged brain ventricles ( J:128724 )

• all ventricles are enlarged

abnormal innervation ( J:128724 )

• axons cross the midline in the spinal cord

abnormal central pattern generator function ( J:128724 )

• mice lose left-right coordination of hindlimb central pattern generator

behavior/neurological

abnormal gait ( J:128724 )

• at the onset of locomotion mice display a rabbit-like hopping gait

unidirectional circling ( J:128724 )

• mice exhibit a tendency towards rightward circling

tonic seizures ( J:128724 )

growth/size/body

decreased body size ( J:128724 )

• shortly after birth mice are smaller than wild-type but reach normal size by adulthood

cellular

abnormal axon extension ( J:128724 )

• fewer growth cones collapse in culture when neurons are treated with Efnb3 or Efna1 compared to in wild-type cultures