Phenotypes associated with this allele

• Allele Symbol: Pdgfc^tm1.1Hdin
• Allele Name: targeted mutation 1.1, Hao Ding
• Allele ID: MGI:3768438
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfc^tm1.1Hdin/Pdgfc^tm1.1Hdin	involves: 129 * C57BL/6 * FVB/N * SJL	MGI:3768512

Genotype
MGI:3768512

hm1

• Allelic Composition: Pdgfc^tm1.1Hdin/Pdgfc^tm1.1Hdin
• Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cleft palate and subepithelial blister in the nasal septum of Pdgfc^tm1.1Hdin/Pdgfc^tm1.1Hdin mutants

craniofacial

palatal shelves fail to meet at midline ( J:128709 )

• the two palate shelves did not fuse at the midline at E15.5

cleft secondary palate ( J:128709 )

• at E15.5, mice display a completely cleft of the secondary palate

abnormal nasal septum morphology ( J:128709 )

• mice develop blistering of the subepithelial layer of the nasal septum

respiratory system

abnormal nasal septum morphology ( J:128709 )

• mice develop blistering of the subepithelial layer of the nasal septum

digestive/alimentary system

palatal shelves fail to meet at midline ( J:128709 )

• the two palate shelves did not fuse at the midline at E15.5

cleft secondary palate ( J:128709 )

• at E15.5, mice display a completely cleft of the secondary palate

integument

blistering ( J:128709 )

• mice develop blistering of the subepithelial layer of the nasal septum

growth/size/body

palatal shelves fail to meet at midline ( J:128709 )

• the two palate shelves did not fuse at the midline at E15.5

cleft secondary palate ( J:128709 )

• at E15.5, mice display a completely cleft of the secondary palate

abnormal nasal septum morphology ( J:128709 )

• mice develop blistering of the subepithelial layer of the nasal septum