Phenotypes associated with this allele

• Allele Symbol: Tg(OPN1LW-DT)1Mame
• Allele Name: transgene insertion 1, Markus Meister
• Allele ID: MGI:3767977
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(OPN1LW-DT)1Mame/0 Tg(OPN1LW-lacZ)1Nat/0	involves: A/J * C57BL/6 * C57BL/6J	MGI:3767984
cx2	Pde6b^rd1/Pde6b^rd1 Tg(OPN1LW-DT)1Mame/?	involves: C3H/He * C57BL/6 * C57BL/6J	MGI:3767983
cx3	Pde6b^rd1/Pde6b^rd1 Tg(OPN1LW-DT)1Mame/?	Not Specified	MGI:5694631

Genotype
MGI:3767984

cx1

• Allelic Composition: Tg(OPN1LW-DT)1Mame/0; Tg(OPN1LW-lacZ)1Nat/0
• Genetic Background: involves: A/J * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

absent retina cone cells ( J:128414 )

• all long wave and nearly all short wave cones are lost

• however, the retinal is otherwise normal

abnormal retina outer plexiform layer morphology ( J:128414 )

• mice lack the occasional large presynaptic swellings with multiple ribbon synapses found in wild-type mice

abnormal cone electrophysiology ( J:128414 )

• mice exhibit no detectable response to square wave stimulus at increased intensity of stimulus

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:128414 )

• unlike wild-type mice, both the superior and inferior retina are unresponsive to L-(+)-2-amino-4-phosphonobutyric acid (APB) treatment

• however, the APB-resistance behavior of the rod signal is normal

nervous system

absent retina cone cells ( J:128414 )

• all long wave and nearly all short wave cones are lost

• however, the retinal is otherwise normal

Genotype
MGI:3767983

cx2

• Allelic Composition: Pde6b^rd1/Pde6b^rd1; Tg(OPN1LW-DT)1Mame/?
• Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6J

vision/eye

abnormal retina morphology ( J:128149 )

• the outer retina is lost

• however, melanopsin-containing cells are present and normally distributed

abnormal retina photoreceptor morphology ( J:128478 )

• mice lack immunoreactivity for any of the three photoreceptor types

thin retina inner nuclear layer ( J:128149 )

• transneuronal degeneration results in thinning and regional loss of the inner nuclear layer (INL)

• by 9 months of age only the retinal ganglion layer could be detected in many areas

• the INL never reaches more than 3 to 4 cells deep compared to wild-type INL that are 6 cells deep

abnormal retina outer nuclear layer morphology ( J:128478 )

• mice lack an outer nuclear layer

retina degeneration ( J:128149 )

behavior/neurological

behavior/neurological phenotype ( J:128149 , J:128478 )

N • despite the lack of ability to detect light in their retina, mice maintain normal circadian rhythms (J:128149)

N • despite the lack of ability to detect light in their retina, mice maintain normal circadian rhythms (J:128478)

nervous system

abnormal retina photoreceptor morphology ( J:128478 )

• mice lack immunoreactivity for any of the three photoreceptor types

Genotype
MGI:5694631

cx3

• Allelic Composition: Pde6b^rd1/Pde6b^rd1; Tg(OPN1LW-DT)1Mame/?
• Genetic Background: Not Specified

vision/eye

abnormal visual contrast sensitivity ( J:199509 )

• mice lacking both functional rods and cones are trained to distinguish a bright signal from a dark signal using a water maze

• mice distinguish between targets differing by as little as 13X in radiance