Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-AR*97Q)7-8Sobue
• Allele Name: transgene insertion 7-8, Gen Sobue
• Allele ID: MGI:3767716
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CAG-AR*97Q)7-8Sobue/? Tg(CAG-STUB1)1Sobue/Tg(CAG-STUB1)1Sobue	involves: C57BL/6 * C57BL/6J * DBA/2	MGI:3767787
cx2	Tg(CAG-AR*97Q)7-8Sobue/? Tg(CAG-STUB1)1Sobue/?	involves: C57BL/6 * C57BL/6J * DBA/2	MGI:3767788
tg3	Tg(CAG-AR*97Q)7-8Sobue/?	involves: C57BL/6 * C57BL/6J * DBA/2	MGI:3767789

Genotype
MGI:3767787

cx1

• Allelic Composition: Tg(CAG-AR*97Q)7-8Sobue/?; Tg(CAG-STUB1)1Sobue/Tg(CAG-STUB1)1Sobue
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:121559 )

• motor coordination impairment on a rotarod test is not as sever as in Tg(ACTB-AR*97Q)2-6Sobu male mice but not as improved as in Tg(ACTB-STUB1)Sobu/Tg(ACTB-STUB1)Sobu Tg(ACTB-AR*97Q)2-6Sobu male mice

• male mice took smaller steps when walking than Tg(ACTB-STUB1)Sobu/Tg(ACTB-STUB1)Sobu Tg(ACTB-AR*97Q)2-6Sobu male but longer than Tg(ACTB-AR*97Q)2-6Sobu male mice

muscle

muscular atrophy ( J:121559 )

• muscular atrophy in male mice is less than in Tg(ACTB-AR*97Q)2-6Sobu male mice

growth/size/body

weight loss ( J:121559 )

• male mice do not lose as much weight as quickly as Tg(ACTB-AR*97Q)2-6Sobu mice

Genotype
MGI:3767788

cx2

• Allelic Composition: Tg(CAG-AR*97Q)7-8Sobue/?; Tg(CAG-STUB1)1Sobue/?
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

behavior/neurological

impaired coordination ( J:121559 )

• motor coordination impairment on a rotarod test is not as sever as in Tg(ACTB-AR*97Q)2-6Sobu male mice or Tg(ACTB-STUB1)Sobu Tg(ACTB-AR*97Q)2-6Sobu male mice and begins at 16 weeks

• however, mice walk normally

growth/size/body

weight loss ( J:121559 )

• male mice do not lose as much weight as quickly as Tg(ACTB-AR*97Q)2-6Sobu male mice

Genotype
MGI:3767789

tg3

• Allelic Composition: Tg(CAG-AR*97Q)7-8Sobue/?
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

mortality/aging

premature death ( J:128619 )

• life spans are reduced to 66 to 132 days for male mice from cachexia due to hyponutrition and dehydration

• however, female mice survive past 210 days

• female life span is reduced when treated with testoserone where as male life span is increased following castration

behavior/neurological

impaired coordination ( J:121559 , J:128619 )

• male mice display impaired motor coordination on a rotarod test at 8 weeks of age (J:121559)

• male mice take short steps or drag their feet (J:121559)

• progressive motor impairment as assessed by a rotarod test begins at 8 to 9 weeks of age for male mice and at 15 to 21 weeks for female mice (J:128619)

• female motor coordination is decreased when treated with testosterone whereas males motor coordination improve following castration (J:128619)

decreased locomotor activity ( J:121559 , J:128619 )

• male mice become hypoactive at 32 weeks of age (J:121559)

• male mice display pronounced and accelerated reduction in cage activity compared to female mice (J:128619)

• hypoactivity is increased in female mice following treatment with testosterone (J:128619)

nervous system

abnormal motor neuron morphology ( J:128619 )

• motor neuron cross-sectional area is decreased (130.6+/-4.0 um² compared to 195.6+/-12.1 um² in wild-type mice)

growth/size/body

decreased body size ( J:128619 )

• male mice display pronounced and accelerated reduction in body size compared to female mice

weight loss ( J:121559 , J:128619 )

• male mice lose more weight earlier than Tg(ACTB-STUB1)Sobu/Tg(ACTB-STUB1)Sobu Tg(ACTB-AR*97Q)2-6Sobu mice and Tg(ACTB-STUB1)Sobu Tg(ACTB-AR*97Q)2-6Sobu mice (J:121559)

• weight lose begins at 4 to 6 weeks for male mice and at 12 to 16 weeks for female mice (J:128619)

• weight loss in females is accelerated by treatment with testosterone and decelerated in castrated males (J:128619)

cachexia ( J:128619 )

• male mice die due to cachaxia

muscle

dystrophic muscle ( J:128619 )

• male mice display pronounced and accelerated muscular dystrophy compared to female mice

• male mice display muscular atrophy in the trunk and hindlimbs followed by weight loss and impaired motor coordination

• female muscular dystrophy is worsened by treatment with testosterone whereas it is improved in castrated male mice

muscular atrophy ( J:121559 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kennedy's disease		DOID:0060161	OMIM:313200	J:128519