reproductive system
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• after mice are treated with tamoxifen for 8 weeks, tubules exhibit decreased celullarity and diameter
• tubules containing only Sertoli cells are often observed
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• after mice are treated with tamoxifen for 8 weeks, testis weight is decreased by 50% of wild-type
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• after mice are treated with tamoxifen for 8 weeks, mitotic clusters of cells observed are often stuck in anaphase and abnormal chromosome content is observed
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• after mice are treated with tamoxifen for 8 weeks, no male germ cells are observed
• after mice are treated with tamoxifen for 8 weeks, sperm production is reduced by 80% of wild-type
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• after treated with tamoxifen for 4 weeks, adult males become infertile
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cellular
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• after mice are treated with tamoxifen for 8 weeks, no male germ cells are observed
• after mice are treated with tamoxifen for 8 weeks, sperm production is reduced by 80% of wild-type
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• after mice are treated with tamoxifen for 8 weeks, male testes have reduced mitotic index
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growth/size/body
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• when mice are treated with tamoxifen beginning at E10.5, by E18.5 mice resemble E10.5 to E11.5 mice
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• when mice are treated with tamoxifen beginning at E10.5, by E18.5 mice resemble E10.5 to E11.5 mice
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endocrine/exocrine glands
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• after mice are treated with tamoxifen for 8 weeks, tubules exhibit decreased celullarity and diameter
• tubules containing only Sertoli cells are often observed
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• after mice are treated with tamoxifen for 8 weeks, testis weight is decreased by 50% of wild-type
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