Phenotypes associated with this allele

• Allele Symbol: Tg(THY1-SNCA*A30P)TS2Sud
• Allele Name: transgene insertion TS2, Thomas C Sudhof
• Allele ID: MGI:3767582
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dnajc5^tm1Sud/Dnajc5^tm1Sud Tg(THY1-SNCA*A30P)TS2Sud/0	involves: 129S6/SvEvTac * C57BL/6	MGI:3768115
tg2	Tg(THY1-SNCA*A30P)TS2Sud/0	involves: C57BL/6 * SJL	MGI:3768129

Genotype
MGI:3768115

cx1

• Allelic Composition: Dnajc5^tm1Sud/Dnajc5^tm1Sud; Tg(THY1-SNCA*A30P)TS2Sud/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:115193 )

• lethality is similar to that observed for Dnajc5-deficient mice

growth/size/body

decreased body weight ( J:115193 )

weight loss ( J:115193 )

• mice exhibit relative loss of body weight after P20 similar to non-transgenic Dnajc5-deficient littermates

behavior/neurological

abnormal behavior ( J:115193 )

• mice fail behavioral tests requiring vision

impaired righting response ( J:115193 )

• mice show similar impairment to that seen for Dnajc5-deficient mice; transgene expression does not rescue righting ability

ataxia ( J:115193 )

• expression of mutant human SNCA only partially rescues ataxia observed in Dnajc5-deficient mice

decreased grip strength ( J:115193 )

• in a grip test, mice cannot grip the mesh for very long before dropping, compared to the 2 minute duration of the test achieved by wild-type mice

nervous system

retina photoreceptor degeneration ( J:115193 )

• mice show considerable photoreceptor degeneration

vision/eye

retina photoreceptor degeneration ( J:115193 )

• mice show considerable photoreceptor degeneration

thin retina outer nuclear layer ( J:115193 )

• ONL shrinks dramatically with photoreceptor degeneration

abnormal retina outer plexiform layer morphology ( J:115193 )

• OPL disintegrates in mutants

Genotype
MGI:3768129

tg2

• Allelic Composition: Tg(THY1-SNCA*A30P)TS2Sud/0
• Genetic Background: involves: C57BL/6 * SJL

nervous system

decreased motor neuron number ( J:115193 )

motor neuron degeneration ( J:115193 )

• mice show onset of motoneuron disease at ~9-10 months

alpha-synuclein inclusion body ( J:115193 )

• insoluble alpha-synuclein aggregates form in asymptomatic and symptomatic transgenic mice in terms of neuropathology