Phenotypes associated with this allele

• Allele Symbol: Tg(THY1-Snca)M1mSud
• Allele Name: transgene insertion M1m, Thomas C Sudhof
• Allele ID: MGI:3767580
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dnajc5^tm1Sud/Dnajc5^tm1Sud Tg(THY1-Snca)M1mSud/0	involves: 129S6/SvEvTac * C57BL/6	MGI:3768116
tg2	Tg(THY1-Snca)M1mSud/0	involves: C57BL/6	MGI:3768130

Genotype
MGI:3768116

cx1

• Allelic Composition: Dnajc5^tm1Sud/Dnajc5^tm1Sud; Tg(THY1-Snca)M1mSud/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:115193 )

N • double mutants show rescue of lethality observed for Dnajc5-deficient mice; mice live >15 months

behavior/neurological

behavior/neurological phenotype ( J:115193 )

N • transgenic Dnajc5-deficient mice have righting ability like wild-type mice at all ages

nervous system

retina photoreceptor degeneration ( J:115193 )

• mice show considerable photoreceptor degeneration

vision/eye

retina photoreceptor degeneration ( J:115193 )

• mice show considerable photoreceptor degeneration

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:115193 )

N • weight loss seen in non-transgenic Dnajc5-deficient mice is prevented

Genotype
MGI:3768130

tg2

• Allelic Composition: Tg(THY1-Snca)M1mSud/0
• Genetic Background: involves: C57BL/6

nervous system

nervous system phenotype ( J:115193 )

N • mice do not develop motoneuron disease