Phenotypes associated with this allele

• Allele Symbol: Del(4Cdkn2a-Cdkn2b)2Brn
• Allele Name: deletion, Chr 4, Anton Berns 2
• Allele ID: MGI:3767464
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(4Cdkn2a-Cdkn2b)2Brn/Del(4Cdkn2a-Cdkn2b)2Brn	involves: 129P2/OlaHsd * FVB/N	MGI:3766054
ht2	Del(4Cdkn2a-Cdkn2b)2Brn/+	involves: 129P2/OlaHsd * FVB/N	MGI:3766050

Genotype
MGI:3766054

hm1

• Allelic Composition: Del(4Cdkn2a-Cdkn2b)2Brn/Del(4Cdkn2a-Cdkn2b)2Brn
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:125189 )

• except for skin tumors mice develop similar tumors as homozygous animals

increased tumor latency ( J:125189 )

• mice develop similar tumors as homozygous animals but with much longer latency

Genotype
MGI:3766050

ht2

• Allelic Composition: Del(4Cdkn2a-Cdkn2b)2Brn/+
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

neoplasm

increased tumor incidence ( J:125189 )

• within 7 months mice develop one or more tumors

• tumors are often composed of different cell types and frequently show biphasic morphology

increased intestinal adenocarcinoma incidence ( J:125189 )

• a few mice develop adenocarcinoma of the intestinal tract

increased skin tumor incidence ( J:125189 )

• within 7 months mice develop one or more tumor that are predominantly skin tumor such as squamous cell carcinoma, basal cell carcinoma and tricho-epithelioma/hair-germ-cell tumors

increased leukemia incidence ( J:125189 )

• several mice develop lymphoma and leukemia

increased lymphoma incidence ( J:125189 )

• several mice develop lymphoma and leukemia

increased melanoma incidence ( J:125189 )

• one mouse develops spontaneous melanoma at 3 weeks of age

increased sarcoma incidence ( J:125189 )

• within 7 months mice develop one or more tumor including various soft tissue sarcomas

integument

increased skin tumor incidence ( J:125189 )

• within 7 months mice develop one or more tumor that are predominantly skin tumor such as squamous cell carcinoma, basal cell carcinoma and tricho-epithelioma/hair-germ-cell tumors

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:125189 )

• a few mice develop adenocarcinoma of the intestinal tract