Analysis Tools
mortality/aging
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• mice are born alive but die within 36 hours after birth
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nervous system
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• at P0 elevated apoptosis is detected is confined regions of the forebrain including a region of the septum immediately caudal to the corpus callosum and the cingulate cortex
• increase in apoptosis is lower in the forebrain than in the midbrain or hindbrain
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• clusters of apoptotic cells are detected in confined areas particularly in areas where lesions are observed
• the increase in apoptosis is greater in the hindbrain and midbrain than in the forebrain
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• clusters of apoptotic cells are detected in confined areas particularly in areas where lesions are observed
• the increase in apoptosis is greater in the hindbrain and midbrain than in the forebrain
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• at P0, 2 of 3 homozygotes had enlarged lateral ventricles
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• lesions are present at P0
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• lesions are present at P0
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• lesions are present at P0
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• lesions are present at P0
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• lesions are present at P0
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• lesions are present at P0
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• lesions may be present at P0
• this region of the brain is not as severely affected as the thalamus, hypothalamus or preoptic area
• although neurons appear relatively normal in vivo, vacuoles form in cultured cells
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• lesions may be present at P0
• this region of the brain is not as severely affected as the thalamus, hypothalamus or preoptic area
• although neurons appear relatively normal in vivo, vacuoles form in cultured cells
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• lesions are present at P0
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• lesions are present at P0
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brain lesion
(
J:127106
)
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• at P0 lesions are seen in several brain regions including the preoptic area, thalamus, hypothalamus, midbrain, superior colliculus, pons, medulla, cerebellum, and olfactory bulb
• at P0 the hippocampus and cortex are only mildly affected
• lesions appear to be neuronal cell bodies filled with a grossly enlarged vacuole and/or missing cell bodies from cells that have degenerated
• however, the overall shape of the brain is normal
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• neuronal cell bodies frequently contain vacuoles ranging from multiple small cytoplasmic vacuoles to a single large vacuole that fills the entire cell bod
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• neuronal cell bodies frequently contain vacuoles ranging from multiple small cytoplasmic vacuoles to a single large vacuole that fills the entire cell body
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cardiovascular system
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• significant degeneration of the atria with large, transparent vacuoles
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cellular
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• cultured fibroblasts contain multiple large vacuoles
• results suggest that vacuoles for as a result of a defect in late endosomal functions
• however, in vivo abnormalities are only detected in neuronal cells
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• at P0 elevated apoptosis is detected is confined regions of the forebrain including a region of the septum immediately caudal to the corpus callosum and the cingulate cortex
• increase in apoptosis is lower in the forebrain than in the midbrain or hindbrain
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• clusters of apoptotic cells are detected in confined areas particularly in areas where lesions are observed
• the increase in apoptosis is greater in the hindbrain and midbrain than in the forebrain
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• clusters of apoptotic cells are detected in confined areas particularly in areas where lesions are observed
• the increase in apoptosis is greater in the hindbrain and midbrain than in the forebrain
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