All Phenotypes Immp2l<Tg(Tyr)979Ove> MGI Mouse

• less than 40% of oocytes finish germinal vessel breakdown

• the number of eggs recovered from super ovulation is reduced (1.5 eggs per female compared to 38 oocytes per wild-type females)

abnormal ovary morphology ( J:128071 )

• superovulated ovaries contain defects in preovulatory follicles and trapped oocytes

abnormal ovarian follicle morphology ( J:128071 )

• follicle degeneration with luteinization observed

absent mature ovarian follicles ( J:128071 )

• folliculogenesis fails to proceed past the preantral/early antral stage

impaired ovarian folliculogenesis ( J:128071 )

• folliculogenesis fails to proceed past the preantral/early antral stage

abnormal spermatogenesis ( J:128071 )

• although testes and sperm development are normal at 2 to 3 months of age, by 7 months of age seminiferous tubules display heterogeneous disorganization, vacuolization and reduced germ cell number

oligozoospermia ( J:128071 )

• at 7 months of age the number of germ cells is decreased due to increased apoptosis

• however, germ cell number at 2 to 3 months of age is normal

abnormal penile erection ( J:128071 )

• following stimulation with carbachol (a stimulator of nitrous oxide release) or electrical field stimulation, corpus cavernosum tissue exhibits a decreased response compared to wild-type tissue

• however, the production of nitrous oxide is normal

male infertility ( J:128071 )

• virtually all males fail to produce pups after mating for more than 3 months with proven fertile females

• however, males exhibit normal copulatory behavior and their sexual drive is normal

reduced fertility ( J:128071 )

• both males and females exhibit decreased fertility

abnormal oocyte morphology ( J:128071 )

• less than 40% of oocytes finish germinal vessel breakdown

decreased oocyte number ( J:128071 )

• the number of eggs recovered from super ovulation is reduced (1.5 eggs per female compared to 38 oocytes per wild-type females)

oligozoospermia ( J:128071 )

• at 7 months of age the number of germ cells is decreased due to increased apoptosis

• however, germ cell number at 2 to 3 months of age is normal

abnormal cellular respiration ( J:128071 )

• mitochondria isolated from the testies, spermatozoa, splenic lymphocytes brain are hyperpolarized with higher levels of ATP than in wild-type mice

• rates of superoxide ion generation in the testes, brain and sperm are increased compared to in wild-type mice

• however, mitochondrial number and volume are normal

abnormal respiratory electron transport chain ( J:128071 )

• mitochondrial respiratory complex I and I+III activity are lower than in wild-type mice in the testes

• citrate synthase activity in the testes is lower than in wild-type mice

decreased body weight ( J:128071 )

• mice weight 10% less than wild-type mice

• however, after 4 to 5 months the weight difference is not significant

abnormal ovary morphology ( J:128071 )

• superovulated ovaries contain defects in preovulatory follicles and trapped oocytes

abnormal ovarian follicle morphology ( J:128071 )

• follicle degeneration with luteinization observed

absent mature ovarian follicles ( J:128071 )

• folliculogenesis fails to proceed past the preantral/early antral stage

impaired ovarian folliculogenesis ( J:128071 )

• folliculogenesis fails to proceed past the preantral/early antral stage

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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