Phenotypes associated with this allele

• Allele Symbol: Acsm4^tm1(cre)Hsak
• Allele Name: targeted mutation 1, Hitoshi Sakano
• Allele ID: MGI:3765958
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Acsm4^tm1(cre)Hsak/? Eno2^tm1(DTA)Hsak/?	involves: 129S2/SvPas * C57BL/6	MGI:3766324

Genotype
MGI:3766324

cn1

• Allelic Composition: Acsm4^tm1(cre)Hsak/?; Eno2^tm1(DTA)Hsak/?
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:127822 )

• olfactory sensory neurons are absent in the dorsal zone of the olfactory bulb epithelium

• mitral cells fail to form dendrtic terminal tufts indicating a lack of synaptic input

abnormal olfactory receptor morphology ( J:127822 )

• no expression of class I or class II olfactory receptor genes in the dorsal zone of the olfactory epithelium

abnormal olfaction ( J:127822 )

• the glomeruli of the dorsal zone of the olfactory bulb fail to detect several different odors

• there are decreased numbers of activated cells in the bed nucleus of the stria terminalis after exposure to the odorant trimethyl-thiazoline

behavior/neurological

abnormal olfactory discrimination memory ( J:127822 )

• mice are able to discriminate between structurally related odorants including trimethyl-thiazoline and 2-methylbutyric acid

abnormal sensory capabilities/reflexes/nociception ( J:127822 )

• mice fail to show innate avoidance behavior to unpleasant scents including trimethyl-thiazoline (found in fox urine) and 2-methylbutyric acid (found in spoiled foods)

nervous system

abnormal olfactory sensory neuron morphology ( J:127822 )

• olfactory sensory neurons are absent in the dorsal zone of the olfactory bulb epithelium

• mitral cells fail to form dendrtic terminal tufts indicating a lack of synaptic input

abnormal olfactory receptor morphology ( J:127822 )

• no expression of class I or class II olfactory receptor genes in the dorsal zone of the olfactory epithelium

craniofacial

abnormal olfactory sensory neuron morphology ( J:127822 )

• olfactory sensory neurons are absent in the dorsal zone of the olfactory bulb epithelium

• mitral cells fail to form dendrtic terminal tufts indicating a lack of synaptic input

abnormal olfactory receptor morphology ( J:127822 )

• no expression of class I or class II olfactory receptor genes in the dorsal zone of the olfactory epithelium

respiratory system

abnormal olfactory sensory neuron morphology ( J:127822 )

• olfactory sensory neurons are absent in the dorsal zone of the olfactory bulb epithelium

• mitral cells fail to form dendrtic terminal tufts indicating a lack of synaptic input

abnormal olfactory receptor morphology ( J:127822 )

• no expression of class I or class II olfactory receptor genes in the dorsal zone of the olfactory epithelium

growth/size/body

abnormal olfactory sensory neuron morphology ( J:127822 )

• olfactory sensory neurons are absent in the dorsal zone of the olfactory bulb epithelium

• mitral cells fail to form dendrtic terminal tufts indicating a lack of synaptic input

abnormal olfactory receptor morphology ( J:127822 )

• no expression of class I or class II olfactory receptor genes in the dorsal zone of the olfactory epithelium