Phenotypes associated with this allele

• Allele Symbol: Mex3c^{Gt(DD0642)Wtsi}
• Allele Name: gene trap DD0642, Wellcome Trust Sanger Institute
• Allele ID: MGI:3764947
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mex3c^Gt(DD0642)Wtsi/Mex3c^Gt(DD0642)Wtsi	B6.129P2-Mex3c^Gt(DD0642)Wtsi	MGI:5446040
hm2	Mex3c^Gt(DD0642)Wtsi/Mex3c^Gt(DD0642)Wtsi	FVB.129P2(B6)-Mex3c^Gt(DD0642)Wtsi	MGI:5446041
hm3	Mex3c^Gt(DD0642)Wtsi/Mex3c^Gt(DD0642)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5446039

Genotype
MGI:5446040

hm1

• Allelic Composition: Mex3c^{Gt(DD0642)Wtsi}/Mex3c^{Gt(DD0642)Wtsi}
• Genetic Background: B6.129P2-Mex3c^{Gt(DD0642)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:189503 )

• Background Sensitivity: more than 85% of mice on a C57BL/6 background die within hours of birth unlike mice on a mixed or congenic FVB background

respiratory system

abnormal pulmonary alveolus morphology ( J:189503 )

• poorly expanded alveolar space in neonates

homeostasis/metabolism

cyanosis ( J:189503 )

• in neonates

growth/size/body

postnatal growth retardation ( J:189503 )

• in mice that survive to adulthood

Genotype
MGI:5446041

hm2

• Allelic Composition: Mex3c^{Gt(DD0642)Wtsi}/Mex3c^{Gt(DD0642)Wtsi}
• Genetic Background: FVB.129P2(B6)-Mex3c^{Gt(DD0642)Wtsi}

mortality/aging

mortality/aging ( J:189503 )

N • Background Sensitivity: more than 80% of mice lived to adulthood unlike mice on a congenic C57BL/6 background

skeleton

short tibia ( J:189503 )

abnormal long bone epiphyseal plate morphology ( J:189503 )

• the growth plate contains prehypertrophic stage chondrocytes unlike in wild-type mice

decreased width of hypertrophic chondrocyte zone ( J:189503 )

• with reduced mean height of terminal hypertrophic chondrocytes

decreased long bone epiphyseal plate size ( J:189503 )

homeostasis/metabolism

abnormal insulin-like growth factor I level ( J:189503 )

♀ • reduced in the bone of female mice at 6 to 7 weeks

decreased circulating insulin-like growth factor I level ( J:189503 )

• in female mice at 2 to 3 months

• in male mice at 5 months

growth/size/body

decreased body length ( J:189503 )

• in female mice at 5 months

• in male mice at 6 weeks

postnatal growth retardation ( J:189503 )

limbs/digits/tail

short tibia ( J:189503 )

Genotype
MGI:5446039

hm3

• Allelic Composition: Mex3c^{Gt(DD0642)Wtsi}/Mex3c^{Gt(DD0642)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

mortality/aging ( J:189503 )

N • Background Sensitivity: more than 80% of mice lived to adulthood unlike mice on a congenic C57BL/6 background

skeleton

short tibia ( J:189503 )

abnormal long bone epiphyseal plate morphology ( J:189503 )

• the growth plate contains prehypertrophic stage chondrocytes unlike in wild-type mice

decreased width of hypertrophic chondrocyte zone ( J:189503 )

• with reduced mean height of terminal hypertrophic chondrocytes

decreased long bone epiphyseal plate size ( J:189503 )

growth/size/body

decreased body length ( J:189503 )

• in female mice at 4 weeks

• in male mice at 8 weeks

postnatal growth retardation ( J:189503 )

homeostasis/metabolism

increased circulating growth hormone level ( J:189503 )

♂ • in male mice at 8 weeks

limbs/digits/tail

short tibia ( J:189503 )