Phenotypes associated with this allele

• Allele Symbol: Ep400^tm1Fuku
• Allele Name: targeted mutation 1, Rikiro Fukunaga
• Allele ID: MGI:3764913
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ep400^tm1Fuku/Ep400^tm1Fuku	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3764918

Genotype
MGI:3764918

hm1

• Allelic Composition: Ep400^tm1Fuku/Ep400^tm1Fuku
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:127131 )

• although some mice are present at E10.5, no viable mice are found at E11.5

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:127131 )

• in a colony forming assay, yolk sac cells from E8.5 embryos yield few colonies

• however, the proportion of erythroid colonies is the same as for wild-type cells (67%)

anemia ( J:127131 )

• at E11.5, embryos are anemic in appearance

absent erythrocytes ( J:127131 )

• the embryo proper lacks blood cells

embryo

embryonic growth arrest ( J:127131 )

• mice exhibit developmental arrest at E9.5

abnormal neural tube morphology ( J:127131 )

• at E11.5, mice have slightly deformed neural tubes

wavy neural tube ( J:127131 )

nervous system

abnormal neural tube morphology ( J:127131 )

• at E11.5, mice have slightly deformed neural tubes

wavy neural tube ( J:127131 )