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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm3aGt(YHA186)Byg
gene trap YHA186, BayGenomics
MGI:3764891
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm3aGt(YHA186)Byg/Kdm3aGt(YHA186)Byg involves: 129P2/OlaHsd MGI:3840233
hm2
 		Kdm3aGt(YHA186)Byg/Kdm3aGt(YHA186)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3764912


Genotype
MGI:3840233
hm1
Allelic
Composition		 Kdm3aGt(YHA186)Byg/Kdm3aGt(YHA186)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm3aGt(YHA186)Byg mutation (0 available); any Kdm3a mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
obese ( J:147295 )




Genotype
MGI:3764912
hm2
Allelic
Composition		 Kdm3aGt(YHA186)Byg/Kdm3aGt(YHA186)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm3aGt(YHA186)Byg mutation (0 available); any Kdm3a mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:127121 )
N
• no significant alterations in follicular stimulating hormone, lutenizing hormone, androstenedione, or testosterone levels are detected
asthenozoospermia ( J:127121 )
• despite the presence of tails on all sperm, 98.5% are immotile
abnormal seminiferous tubule morphology ( J:127121 )
• multiple vacuolations present
• however, the morphology of Sertoli and Leydig cells is normal
abnormal sperm head morphology ( J:127121 )
• all epididymal sperm have abnormally shaped heads
abnormal acrosome assembly ( J:127121 )
• although the acrosomal structure appears normal in round spermatids at step 7, it is not fully formed at step 13
abnormal spermatid morphology ( J:127121 )
• fewer elongated spermatids present
• at stage 8 multiple spermatids sharing cytoplasm and with multiple tails are presen
• at stage 11 - 12 spermatids have heads that are not as elongated as in wild-type mice
abnormal spermiogenesis ( J:127121 )
• elongation of spermatids, spermatid separation, and acrosomal formation are impaired
• chromocentre organization of the nucleus and polarity of chromatin distribution are absent
• abnormalities are confined to post-meiotic stages of spermatogenesis
• chromatin condensation is disrupted

cellular
abnormal sperm head morphology ( J:127121 )
• all epididymal sperm have abnormally shaped heads
abnormal acrosome assembly ( J:127121 )
• although the acrosomal structure appears normal in round spermatids at step 7, it is not fully formed at step 13
abnormal spermatid morphology ( J:127121 )
• fewer elongated spermatids present
• at stage 8 multiple spermatids sharing cytoplasm and with multiple tails are presen
• at stage 11 - 12 spermatids have heads that are not as elongated as in wild-type mice
asthenozoospermia ( J:127121 )
• despite the presence of tails on all sperm, 98.5% are immotile

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:127121 )
• multiple vacuolations present
• however, the morphology of Sertoli and Leydig cells is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory