Phenotypes associated with this allele

• Allele Symbol: Epm2a^{Tg(TcraK,TcrbK)TG-BFlv}
• Allele Name: transgene insertion TG-B, Richard A Flavell
• Allele ID: MGI:3764832
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Epm2a^Tg(TcraK,TcrbK)TG-BFlv/Epm2a^+	involves: C57BL/6 * C57BL/10 * C57BR/cd * CBA/J	MGI:5461066
ht2	Epm2a^Tg(TcraK,TcrbK)TG-BFlv/Epm2a^+	involves: C57BL/6J * CBA/J	MGI:3766078
cx3	Epm2a^Tg(TcraK,TcrbK)TG-BFlv/Epm2a^+ Tg(Ela1-TAg)18Bri/0	involves: C57BL/6 * CBA/J * SJL	MGI:3766077

Genotype
MGI:5461066

ht1

• Allelic Composition: Epm2a^{Tg(TcraK,TcrbK)TG-BFlv}/Epm2a⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * C57BR/cd * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:112696 )

• maximum survival is 9 months

• median survival is 6 months

neoplasm

increased T cell derived lymphoma incidence ( J:112696 )

• variable T cell lymphoma first observed in the lymphoid organs (thymus, spleen and lymph nodes) then infiltrating liver, kidney, lung, pancreas, intestines and salivary glands

• however, over-expression of the disrupted gene decreases incidence and delays onset

cellular

abnormal DNA methylation ( J:112696 )

• hypermethylation of the endogenous promoter near transgene insertion

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:112696 )

• variable T cell lymphoma first observed in the lymphoid organs (thymus, spleen and lymph nodes) then infiltrating liver, kidney, lung, pancreas, intestines and salivary glands

• however, over-expression of the disrupted gene decreases incidence and delays onset

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lymphoma		DOID:0060058		J:112696

Genotype
MGI:3766078

ht2

• Allelic Composition: Epm2a^{Tg(TcraK,TcrbK)TG-BFlv}/Epm2a⁺
• Genetic Background: involves: C57BL/6J * CBA/J

immune system

increased CD8-positive, alpha-beta T cell number ( J:107545 )

• CD4/CD8 ratio of peripheral T cells is heavily skewed to CD8+ cells

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:107545 )

• CD4/CD8 ratio of peripheral T cells is heavily skewed to CD8+ cells

Genotype
MGI:3766077

cx3

• Allelic Composition: Epm2a^{Tg(TcraK,TcrbK)TG-BFlv}/Epm2a⁺; Tg(Ela1-TAg)18Bri/0
• Genetic Background: involves: C57BL/6 * CBA/J * SJL

immune system

pancreas inflammation ( J:107545 )

• at 10 weeks, focal perivascular infiltrate is detected

• some 10-20 week-old mice show diffuse immune infiltrate with tissue destruction; animals may show parenchymal infiltrate without tissue destruction or a primarily perivascular infiltrate

endocrine/exocrine glands

abnormal pancreas morphology ( J:107545 )

• at 10-12 weeks of age, prominent TAg-induced dysplasia is observed; atypia in cell nuclei and acinar architectural distortion are seen

abnormal exocrine pancreas morphology ( J:107545 )

• pancreas shows exocrine tissue destruction

pancreas inflammation ( J:107545 )

• at 10 weeks, focal perivascular infiltrate is detected

• some 10-20 week-old mice show diffuse immune infiltrate with tissue destruction; animals may show parenchymal infiltrate without tissue destruction or a primarily perivascular infiltrate

digestive/alimentary system

abnormal exocrine pancreas morphology ( J:107545 )

• pancreas shows exocrine tissue destruction