Phenotypes associated with this allele

• Allele Symbol: Tg(Cryaa-TAg)7488Lmgd
• Allele Name: transgene insertion 7488, Laboratory of Mammalian Genes and Development, Heiner Westphal
• Allele ID: MGI:3764829
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Cryaa-TAg)7488Lmgd/?	Not Specified	MGI:3764897

Genotype
MGI:3764897

tg1

• Allelic Composition: Tg(Cryaa-TAg)7488Lmgd/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye morphology ( J:127709 )

• invasive growth of lens breaks through the back of the eye in older animals (>2 months)

increased eye tumor incidence ( J:127709 )

• cells of lens masses have characteristics of transformed (tumor) cells including lack of contact inhibition and rapid growth

• at 10-15 days of age, differentiation of fiber cells is affected, with the anaplastic cells (that are present in more advanced tumors ) visualized in the posterior lens compartment

• lens oncogenesis is well-progressed in all mice by 2 to 3 months

abnormal cornea morphology ( J:127709 )

• invasive growth of lens eventually breaks through cornea at front of eye

abnormal lens morphology ( J:127709 )

• in animals older than 2 months, lens is replaced by a disorganized mass that has grown outside the lens capsule

• lens (or disorganized mass) has become infiltrated by blood vessels in animals >2 months

• much of lens is composed of small, mitotically active anaplastic cells

• a few large, abnormal differentiated lens cells (balloon cells) are distributed throughout tissue

abnormal lens development ( J:127709 )

• by day 12 of embryogenesis, nuclear packing density in posterior region of the vesicle is higher than in control lenses

• mitotically active cells, normally absent in the fiber region, are observed, especially near the lumen; cells near the lumen are round, whereas normal cells are slightly elongated

• by day 13, a disorganized array of small, mitotically active cells have replaced the longitudinally ordered array of primary fiber cells that is seen in normal lenses

• elongated cells are still present at the posterior periphery of the lens at day 13 but they do not persist past this stage; more developed lenses contain only small round cells in posterior compartment

abnormal lens epithelium morphology ( J:127709 )

• some normal epithelium cells are present although they are often displaced into the interior of the lens

• a multilayered epithelium is observed in many areas of the lens

abnormal lens fiber morphology ( J:127709 )

• elongated fiber cells seen in normal lens are absent in transgenic lenses

neoplasm

abnormal tumor incidence ( J:127709 )

• some animals surviving beyond 5 months of age develop non-lenticular tumors at various sites throughout the body

increased eye tumor incidence ( J:127709 )

• cells of lens masses have characteristics of transformed (tumor) cells including lack of contact inhibition and rapid growth

• at 10-15 days of age, differentiation of fiber cells is affected, with the anaplastic cells (that are present in more advanced tumors ) visualized in the posterior lens compartment

• lens oncogenesis is well-progressed in all mice by 2 to 3 months