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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cd4-DsRed)4Lt
transgene insertion 4, Edward Leiter
MGI:3764727
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Cd4-DsRed)4Lt/Tg(Cd4-DsRed)4Lt NOD/ShiLt-Tg(Cd4-DsRed)4Lt MGI:3764841
tg2
 		Tg(Cd4-DsRed)4Lt/0 NOD/ShiLt-Tg(Cd4-DsRed)4Lt MGI:3764840


Genotype
MGI:3764841
tg1
Allelic
Composition		 Tg(Cd4-DsRed)4Lt/Tg(Cd4-DsRed)4Lt
Genetic
Background		 NOD/ShiLt-Tg(Cd4-DsRed)4Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-DsRed)4Lt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:127785 )
• live homozygous animals have not been identified




Genotype
MGI:3764840
tg2
Allelic
Composition		 Tg(Cd4-DsRed)4Lt/0
Genetic
Background		 NOD/ShiLt-Tg(Cd4-DsRed)4Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-DsRed)4Lt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:127785 )
• diabetes incidence (50%) is lower than that displayed by control NOD/ShiLt animals; diabetes onset is delayed relative to control NOD/ShiLt




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory