All Phenotypes Varc MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Varc
variable circling
MGI:3764556

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Varc/Varc⁺	C3H/HeJ-Varc/J	MGI:5897787
ht2	Varc/Varc⁺	C3OuJ.C3-Varc/Kjn	MGI:5897791

Allelic Composition	Varc/Varc⁺
Genetic Background	C3H/HeJ-Varc/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Varc mutation (2 available); any Varc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired swimming ( J:241135 )

• one heterozgyote was tested and failed to orient in water

head tossing ( J:241135 )

• heterozygotes display head tossing and this phenotype is less evident when outcrossed to CAST/EiJ

circling ( J:241135 )

• Background Sensitivity: heterozygotes have a mild circling phenotype and this is less evident when outcrossed to CAST/EiJ

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:241135 )

• all mutants identified with head tossing and circling also have elevated ABR thresholds

increased susceptibility to otitis media ( J:241135 )

• some, but not all, heterozygotes that display head tossing, circling, and elevated ABR thresholds also have otitis media, and this is a secondary phenotype

immune system

increased susceptibility to otitis media ( J:241135 )

• some, but not all, heterozygotes that display head tossing, circling, and elevated ABR thresholds also have otitis media, and this is a secondary phenotype

Allelic Composition	Varc/Varc⁺
Genetic Background	C3OuJ.C3-Varc/Kjn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Varc mutation (2 available); any Varc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

head tossing ( J:241135 )

• heterozygotes display head tossing

circling ( J:241135 )

• Background Sensitivity: heterozygotes have a mild circling phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:241135 )

• all mutants identified with head tossing and circling also have elevated ABR thresholds

increased susceptibility to otitis media ( J:241135 )

• even in the presence of wild-type TLR4 some, but not all, heterozygotes that display head tossing, circling, and elevated ABR thresholds also have otitis media

immune system

increased susceptibility to otitis media ( J:241135 )

• even in the presence of wild-type TLR4 some, but not all, heterozygotes that display head tossing, circling, and elevated ABR thresholds also have otitis media

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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