Phenotypes associated with this allele

• Allele Symbol: Ttn^tm1Mgot
• Allele Name: targeted mutation 1, Michael Gotthardt
• Allele ID: MGI:3763610
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttn^tm1Mgot/Ttn^tm1Mgot	involves: 129 * C57BL/6	MGI:3763611

Genotype
MGI:3763611

hm1

• Allelic Composition: Ttn^tm1Mgot/Ttn^tm1Mgot
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart weight ( J:125922 )

• decreased ventricular weight-to-body weight ratio

ventricular hypoplasia ( J:125922 )

• reduced ventricular dimensions including reduced internal diameter and diastolic volume as determined by echocardiograph

decreased diastolic filling velocity ( J:125922 )

• there is 1.4 fold reduction in the mitral valve deceleration time, and in increase in the E:A wave ratio indicating filling of the ventricle is restricted

abnormal myocardial fiber physiology ( J:125922 )

• the passive tension of cardiac myocytes is significantly increased

muscle

abnormal sarcomere morphology ( J:125922 )

• the slack sarcomere length is reduced significantly from 1.9 micrometers to 1.8