About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gabpatm1Agro
targeted mutation 1, Alan G Rosmarin
MGI:3763374
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gabpatm1Agro/Gabpatm1Agro involves: 129 MGI:3763382
cn2
 		Gabpatm1Agro/Gabpatm1Agro involves: 129 MGI:3763383


Genotype
MGI:3763382
hm1
Allelic
Composition		 Gabpatm1Agro/Gabpatm1Agro
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabpatm1Agro mutation (0 available); any Gabpa mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:126422 )
N
• embryos are born in expected Mendelian ratio with normal embryonic development




Genotype
MGI:3763383
cn2
Allelic
Composition		 Gabpatm1Agro/Gabpatm1Agro
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabpatm1Agro mutation (0 available); any Gabpa mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cell mass ( J:126422 )
• cre-transduced mouse embryonic fibroblasts are enlarged and have abnormally increased cytoplasm
abnormal cell cycle checkpoint function ( J:126422 )
• cre-transduced mouse embryonic fibroblasts exhibit a reduction of cells in S-phase (less than 5% compared to 33% of wild-type cells)
decreased fibroblast proliferation ( J:126422 )
• cre-transduced mouse embryonic fibroblasts fail to proliferate
• however, no increase in apoptosis is observed
decreased DNA replication ( J:126422 )
• cre-transduced mouse embryonic fibroblasts are unable to replicate their DNA or enter S-phase following serum stimulation
• however, RNA and protein synthesis is normal

homeostasis/metabolism
decreased DNA replication ( J:126422 )
• cre-transduced mouse embryonic fibroblasts are unable to replicate their DNA or enter S-phase following serum stimulation
• however, RNA and protein synthesis is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory