Phenotypes associated with this allele

• Allele Symbol: Grk2^tm1.1Gwd
• Allele Name: targeted mutation 1.1, Gerald W Dorn II
• Allele ID: MGI:3763201
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grk2^tm1.1Gwd/Grk2^tm1.1Gwd	involves: 129S4/SvJaeSor * FVB/N	MGI:3763209

Genotype
MGI:3763209

hm1

• Allelic Composition: Grk2^tm1.1Gwd/Grk2^tm1.1Gwd
• Genetic Background: involves: 129S4/SvJaeSor * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:126501 )

• fewer than expected mice are present at E10.5 and by E11.5 no mice are recovered

cardiovascular system

abnormal heart tube morphology ( J:126501 )

• at E9.5, the single ventricle is hypoplastic and ventricular muscle is only 1-cell layer thick

pericardial edema ( J:126501 )

• at E9.5, some mice exhibit pericardial edema

embryo

embryonic growth arrest ( J:126501 )

• embryonic development arrests at E8.5 or E9

embryonic growth retardation ( J:126501 )

• at E10.5, embryonic development is delayed

homeostasis/metabolism

pericardial edema ( J:126501 )

• at E9.5, some mice exhibit pericardial edema

growth/size/body

embryonic growth retardation ( J:126501 )

• at E10.5, embryonic development is delayed