All Phenotypes Prnp<tm2(PRNP*129M)Tkit> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prnp^{tm2(PRNP*129M)Tkit}
targeted mutation 2, Tetsuyuki Kitamoto
MGI:3762784

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prnp^{tm2(PRNP129M)Tkit}/Prnp^{tm2(PRNP129M)Tkit}	Not Specified	MGI:3762814
ht2	Prnp^{tm2(PRNP129M)Tkit}/Prnp^{tm3(PRNP129V)Tkit}	Not Specified	MGI:3762813
cx3	Prnp^{tm2(PRNP129M)Tkit}/Prnp^{tm2(PRNP129M)Tkit} Tg(Prnp-PRNP*129M)1Tkit/?	Not Specified	MGI:3762870

Allelic Composition	Prnp^{tm2(PRNP129M)Tkit}/Prnp^{tm2(PRNP129M)Tkit}
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp^{tm2(PRNP*129M)Tkit} mutation (0 available); any Prnp mutation (150 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to prion infection ( J:105882 , J:126777 )

• one mouse was are weakly susceptible while others are not susceptible to bovine spongiform encephalopathy prion infection (J:105882)

• mice are less susceptible to infection with non-plaque-type dura matter graft-associated Creutzfeldt-Jakob and sporadic Creutzfeldt-Jakob VV2 than Prnp^{tm3(PRNP*129V)Tkit} homozygotes (J:126777)

increased susceptibility to prion infection ( J:105882 , J:126777 )

• mice are highly susceptible to variant Creutzfeldt-Jakob prion infection (J:105882)

• incubation period following infection with sporadic Creutzfeldt-Jakob MM1 prion infection is 467+/-24 days compared to 542 and 648 days for 2 Prnp^{tm3(PRNP*129V)Tkit} homozygous mice (J:126777)

Allelic Composition	Prnp^{tm2(PRNP129M)Tkit}/Prnp^{tm3(PRNP129V)Tkit}
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp^{tm2(PRNP*129M)Tkit} mutation (0 available); any Prnp mutation (150 available)
Prnp^{tm3(PRNP*129V)Tkit} mutation (0 available); any Prnp mutation (150 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to prion infection ( J:105882 )

• mice are weakly susceptible to variant Creutzfeldt-Jakob prion infection

Allelic Composition	Prnp^{tm2(PRNP129M)Tkit}/Prnp^{tm2(PRNP129M)Tkit} Tg(Prnp-PRNP*129M)1Tkit/?
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnp^{tm2(PRNP*129M)Tkit} mutation (0 available); any Prnp mutation (150 available)
Tg(Prnp-PRNP*129M)1Tkit mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to prion infection ( J:126777 )

• incubation period following infection with sporadic Creutzfeldt-Jakob VV2 prions is 723+/-79 days compared to 312+/-7 days for Prnp^{tm3(PRNP*129V)Tkit} homozygous mice

increased susceptibility to prion infection ( J:126777 )

• incubation period following infection with sporadic Creutzfeldt-Jakob MM1 prions is 429+/-6 days compared to 542 and 648 days for 2 Prnp^{tm3(PRNP*129V)Tkit} homozygous mice

nervous system

abnormal brain morphology ( J:126777 )

• following infection with sporadic Creutzfeldt-Jakob MM1 prion, mice exhibit diffuse synaptic-type prion protein deposits

• following infection with sporadic Creutzfeldt-Jakob VV2 prion, mice exhibit more prominent plaque-type prion protein deposits with larger plaque-type deposits spread throughout the cerebral gray matter and thalamus rather than the white matter

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