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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ins2-cre)6Lt
transgene insertion 6, Edward Leiter
MGI:3762760
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Ins2-cre)6Lt/Tg(Ins2-cre)6Lt NOD/ShiLt-Tg(Ins2-cre)6Lt MGI:3762925
tg2
 		Tg(Ins2-cre)6Lt/0 NOD/ShiLt-Tg(Ins2-cre)6Lt MGI:3762929


Genotype
MGI:3762925
tg1
Allelic
Composition		 Tg(Ins2-cre)6Lt/Tg(Ins2-cre)6Lt
Genetic
Background		 NOD/ShiLt-Tg(Ins2-cre)6Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-cre)6Lt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:127015 )
• no homozygous offspring are generated by hemizygous crossing




Genotype
MGI:3762929
tg2
Allelic
Composition		 Tg(Ins2-cre)6Lt/0
Genetic
Background		 NOD/ShiLt-Tg(Ins2-cre)6Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-cre)6Lt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:127015 )
• hemizygotes are viable and fertile; diabetes progression is normal compared to NOD/ShiLt controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory