All Phenotypes Zpbp<tm1Zuk> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zpbp^tm1Zuk/Zpbp^tm1Zuk	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3762591
ht2	Zpbp^tm1Zuk/Zpbp⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3762593
cx3	Zpbp^tm1Zuk/Zpbp^tm1Zuk Zpbp2^tm1Zuk/Zpbp2^tm1Zuk	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3762594
cx4	Zpbp^tm1Zuk/Zpbp⁺ Zpbp2^tm1Zuk/Zpbp2^tm1Zuk	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3762595
cx5	Zpbp^tm1Zuk/Zpbp⁺ Zpbp2^tm1Zuk/Zpbp2⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3762596

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:126661 )

N	• total testis weight is similar to wild-type and heterozygous littermates

asthenozoospermia ( J:126661 )

• only about 10% of sperm are motile compared to 68% motility in controls

abnormal Sertoli cell morphology ( J:126661 )

• abnormal vesicles made of acrosome fragments coated with junctional structures are present in the cytoplasm

abnormal spermatogenesis ( J:126661 )

• profound fragmentation and degradation of the acrosome in spermatids

teratozoospermia ( J:126661 )

• additional abnormalities including misshapen nuclei, detached flagella, and disorganized mitochondria within excessive cytoplasmic droplets are seen

abnormal sperm flagellum morphology ( J:126661 )

• disorganized mitochondria within excessive cytoplasmic droplets are seen

coiled sperm flagellum ( J:126661 )

• the proportion of sperm with coiled flagella increases from the proximal caput epididymis to the caudal epididymis

detached sperm flagellum ( J:126661 )

abnormal acrosome morphology ( J:126661 )

• only abnormally shaped acrosome fragments are seen in ~20% of sperm

globozoospermia ( J:126661 )

• most caudal epididymal sperm have a round-head with the tail coiled around the nucleus

absent acrosome ( J:126661 )

• the acrosome is absent in over 80% of sperm

abnormal sperm nucleus morphology ( J:126661 )

• misshapen nuclei are observed

abnormal spermatid morphology ( J:126661 )

• dilated acrosome, detached of eccentric acrosomal granules, and occasional nuclear indentation by the dilated acrosome are seen as early as in step 6 to 8 spermatids

male infertility ( J:126661 )

• secondary to globozoospermia

• despite normal sperm counts

• however, female fertility is normal

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:126661 )

• abnormal vesicles made of acrosome fragments coated with junctional structures are present in the cytoplasm

cellular

teratozoospermia ( J:126661 )

• additional abnormalities including misshapen nuclei, detached flagella, and disorganized mitochondria within excessive cytoplasmic droplets are seen

abnormal sperm flagellum morphology ( J:126661 )

• disorganized mitochondria within excessive cytoplasmic droplets are seen

coiled sperm flagellum ( J:126661 )

• the proportion of sperm with coiled flagella increases from the proximal caput epididymis to the caudal epididymis

detached sperm flagellum ( J:126661 )

abnormal acrosome morphology ( J:126661 )

• only abnormally shaped acrosome fragments are seen in ~20% of sperm

globozoospermia ( J:126661 )

• most caudal epididymal sperm have a round-head with the tail coiled around the nucleus

absent acrosome ( J:126661 )

• the acrosome is absent in over 80% of sperm

abnormal sperm nucleus morphology ( J:126661 )

• misshapen nuclei are observed

abnormal spermatid morphology ( J:126661 )

• dilated acrosome, detached of eccentric acrosomal granules, and occasional nuclear indentation by the dilated acrosome are seen as early as in step 6 to 8 spermatids

asthenozoospermia ( J:126661 )

• only about 10% of sperm are motile compared to 68% motility in controls

Allelic Composition	Zpbp^tm1Zuk/Zpbp⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zpbp^tm1Zuk mutation (1 available); any Zpbp mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

teratozoospermia ( J:126661 )

• increase in the percentage of abnormal sperm

• however, fecundity is similar to wild-type males

cellular

teratozoospermia ( J:126661 )

• increase in the percentage of abnormal sperm

• however, fecundity is similar to wild-type males

Allelic Composition	Zpbp^tm1Zuk/Zpbp^tm1Zuk Zpbp2^tm1Zuk/Zpbp2^tm1Zuk
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zpbp2^tm1Zuk mutation (1 available); any Zpbp2 mutation (25 available)
Zpbp^tm1Zuk mutation (1 available); any Zpbp mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

asthenozoospermia ( J:126661 )

• only about 10% of sperm are motile compared to 68% motility in controls

abnormal Sertoli cell morphology ( J:126661 )

• abnormal vesicles made of acrosome fragments coated with junctional structures are present in the cytoplasm

abnormal spermatogenesis ( J:126661 )

• profound fragmentation and degradation of the acrosome in spermatids

teratozoospermia ( J:126661 )

• additional abnormalities including misshapen nuclei, detached flagella, and disorganized mitochondria within excessive cytoplasmic droplets are seen

abnormal sperm flagellum morphology ( J:126661 )

• disorganized mitochondria within excessive cytoplasmic droplets are seen

coiled sperm flagellum ( J:126661 )

• the proportion of sperm with coiled flagella increases from the proximal caput epididymis to the caudal epididymis

detached sperm flagellum ( J:126661 )

abnormal acrosome morphology ( J:126661 )

• only abnormally shaped acrosome fragments are seen in ~20% of sperm

globozoospermia ( J:126661 )

• most caudal epididymal sperm have a round-head with the tail coiled around the nucleus

absent acrosome ( J:126661 )

• the acrosome is absent in over 80% of sperm

abnormal sperm nucleus morphology ( J:126661 )

• misshapen nuclei are observed

abnormal spermatid morphology ( J:126661 )

• dilated acrosome, detached of eccentric acrosomal granules, and occasional nuclear indentation by the dilated acrosome are seen as early as in step 6 to 8 spermatids

male infertility ( J:126661 )

• associated with severe deformation of the spermatozoa

• despite normal sperm counts

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:126661 )

• abnormal vesicles made of acrosome fragments coated with junctional structures are present in the cytoplasm

cellular

teratozoospermia ( J:126661 )

• additional abnormalities including misshapen nuclei, detached flagella, and disorganized mitochondria within excessive cytoplasmic droplets are seen

abnormal sperm flagellum morphology ( J:126661 )

• disorganized mitochondria within excessive cytoplasmic droplets are seen

coiled sperm flagellum ( J:126661 )

• the proportion of sperm with coiled flagella increases from the proximal caput epididymis to the caudal epididymis

detached sperm flagellum ( J:126661 )

abnormal acrosome morphology ( J:126661 )

• only abnormally shaped acrosome fragments are seen in ~20% of sperm

globozoospermia ( J:126661 )

• most caudal epididymal sperm have a round-head with the tail coiled around the nucleus

absent acrosome ( J:126661 )

• the acrosome is absent in over 80% of sperm

abnormal sperm nucleus morphology ( J:126661 )

• misshapen nuclei are observed

abnormal spermatid morphology ( J:126661 )

• dilated acrosome, detached of eccentric acrosomal granules, and occasional nuclear indentation by the dilated acrosome are seen as early as in step 6 to 8 spermatids

asthenozoospermia ( J:126661 )

• only about 10% of sperm are motile compared to 68% motility in controls

Allelic Composition	Zpbp^tm1Zuk/Zpbp⁺ Zpbp2^tm1Zuk/Zpbp2^tm1Zuk
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

teratozoospermia ( J:126661 )

• increase in the percentage of abnormal sperm

reduced male fertility ( J:126661 )

• average litter size and number of litters over 6 months are significantly reduced compared to wild-type males

• reduction is greater than that seen in double heterozygous males

cellular

teratozoospermia ( J:126661 )

• increase in the percentage of abnormal sperm

Allelic Composition	Zpbp^tm1Zuk/Zpbp⁺ Zpbp2^tm1Zuk/Zpbp2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

teratozoospermia ( J:126661 )

• increase in the percentage of abnormal sperm

reduced male fertility ( J:126661 )

• average litter size and number of litters over 6 months are slightly but significantly reduced compared to wild-type males

cellular

teratozoospermia ( J:126661 )

• increase in the percentage of abnormal sperm

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