All Phenotypes Trp53<tm5Xu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm5Xu
targeted mutation 5, Yang Xu
MGI:3762531

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm5Xu/Trp53^tm5Xu	Not Specified	MGI:3767798

Allelic Composition	Trp53^tm5Xu/Trp53^tm5Xu
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm5Xu mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased apoptosis ( J:126497 )

• p53-dependent cell-cycle arrest and apoptosis were abolished

spontaneous chromosome breakage ( J:126497 )

• interchromosomal translocations were detected in 35% of pre-tumor thymus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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