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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ccl19tm1Cys
targeted mutation 1, Jason G Cyster
MGI:3762257
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ccl19tm1Cys/Ccl19tm1Cys B6.129X1-Ccl19tm1Cys MGI:3762258
hm2
Ccl19tm1Cys/Ccl19tm1Cys involves: 129X1/SvJ MGI:6149991


Genotype
MGI:3762258
hm1
Allelic
Composition
Ccl19tm1Cys/Ccl19tm1Cys
Genetic
Background
B6.129X1-Ccl19tm1Cys
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl19tm1Cys mutation (1 available); any Ccl19 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• despite lowered T cell numbers, mice exhibit normal short-term migration of naive T lymphocytes
• mice have fewer CD4+ and CD8+ T cells
• however, mice exhibit normal B cell numbers
• mice exhibit a 30% reduction in T cells that is not thymus-dependent and likely due to a decrease in T cell survival

hematopoietic system
• mice have fewer CD4+ and CD8+ T cells
• however, mice exhibit normal B cell numbers
• mice exhibit a 30% reduction in T cells that is not thymus-dependent and likely due to a decrease in T cell survival




Genotype
MGI:6149991
hm2
Allelic
Composition
Ccl19tm1Cys/Ccl19tm1Cys
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl19tm1Cys mutation (1 available); any Ccl19 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal sized thymus medulla and no lacrimal and salivary glands inflammation





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory