Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cops8tm1.1Nwe mutation
(0 available);
any
Cops8 mutation
(20 available)
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mortality/aging
embryo
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• during in vitro outgrowth, inner cell mass blastocysts of E3.5 embryos arrest prematurely
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growth/size/body
cellular
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• during in vitro outgrowth, inner cell mass blastocysts of E3.5 embryos arrest prematurely
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cops8tm1.1Nwe mutation
(0 available);
any
Cops8 mutation
(20 available)
Cops8tm1Nwe mutation
(1 available);
any
Cops8 mutation
(20 available)
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cellular
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• following exposure to a cre-retrovirus, mouse embryonic fibroblast cells cannot enter the cell cycle from quiescence induced by serum starvation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cops8tm1.1Nwe mutation
(0 available);
any
Cops8 mutation
(20 available)
Cops8tm1Nwe mutation
(1 available);
any
Cops8 mutation
(20 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• mature T cell numbers in the spleen and lymph nodes are decreased compared to in Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes
• however, the proportion of T cells with naive, memory and regulatory phenotypes are normal
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• CD4+ T cells are less responsive to IL-7 and exhibit a reduced survival compared to CD4+ T cells from IL-7-treated Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes
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• increase in cellular size following stimulation, an indication of activation, is substantially reduced in T cells compared to in T cells from Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes
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• T cells stimulated with anti-CD3 and anti-CD28 or with phorbol 12-myristate 13-acetate (PMA) and ionomycin fail to proliferate as well as T cells from Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes even with the addition of IL-2
• cell cycling in T cells is reduced or absent compared to in T cells from Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes
• however, no increase in T cell apoptosis is observed
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• T cells stimulated with anti-CD3 and anti-CD28 or with phorbol 12-myristate 13-acetate (PMA) and ionomycin produce less IL-2 than similarly treated wild-type cells
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hematopoietic system
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• mature T cell numbers in the spleen and lymph nodes are decreased compared to in Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes
• however, the proportion of T cells with naive, memory and regulatory phenotypes are normal
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• CD4+ T cells are less responsive to IL-7 and exhibit a reduced survival compared to CD4+ T cells from IL-7-treated Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes
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• increase in cellular size following stimulation, an indication of activation, is substantially reduced in T cells compared to in T cells from Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes
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• T cells stimulated with anti-CD3 and anti-CD28 or with phorbol 12-myristate 13-acetate (PMA) and ionomycin fail to proliferate as well as T cells from Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes even with the addition of IL-2
• cell cycling in T cells is reduced or absent compared to in T cells from Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes
• however, no increase in T cell apoptosis is observed
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cellular
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• T cells stimulated with anti-CD3 and anti-CD28 or with phorbol 12-myristate 13-acetate (PMA) and ionomycin fail to proliferate as well as T cells from Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes even with the addition of IL-2
• cell cycling in T cells is reduced or absent compared to in T cells from Cops8tm1Nwe Tg(CD4-cre)1Cwi heterozygotes
• however, no increase in T cell apoptosis is observed
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