Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il36rntm1Hblu mutation
(0 available);
any
Il36rn mutation
(22 available)
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immune system
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• mice develop more severe imiquimod-induced skin inflammation and psoriasis than wild-type mice
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integument
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• mice develop more severe imiquimod-induced skin inflammation and psoriasis than wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il36rntm1Hblu mutation
(0 available);
any
Il36rn mutation
(22 available)
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normal phenotype
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• mice display no overt phenotype including normal histopathology and immune system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il36rntm1Hblu mutation
(0 available);
any
Il36rn mutation
(22 available)
Tg(KRT14-Il1f6)1Hblu mutation
(0 available)
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mortality/aging
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• only 1 mouse was found at weaning and 13 dead mice were recovered prior to weaning with milk in their stomachs but small and dehydrated
• however, treatment with 50 ug M616 at P1, 3 and 5 rescues lethality
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cardiovascular system
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• mice exhibit a dilation of superficial dermal blood vessels
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growth/size/body
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• mice that die during the postnatal period have a dehydrated appearance
• however, skin barrier function at E18.5 and P3 is normal
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• mice are smaller than wild-type mice
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immune system
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• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
• while treatment with 50 ug M616 at P1, 3 and 5 rescues lethality mice develop severe lesions on their face, neck and ears by 4 to 6 weeks when the treatment is withdrawn
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integument
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• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
• while treatment with 50 ug M616 at P1, 3 and 5 rescues lethality mice develop severe lesions on their face, neck and ears by 4 to 6 weeks when the treatment is withdrawn
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• mice exhibit intracorneal and intraepithelial pustules, nucleated corneocytes, parakerototic and orthokeratotic hyperkeratinosis, dilated superficial dermal blood vessels, and a mixed dermal inflammatory infiltrate
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• mice exhibit orthokeratotic hyperkeratinosis
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• mice exhibit parakerototic hyperkeratinosis
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• at P3 mice develop an abnormal skin phenotype resembling blistering
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il36rntm1Hblu mutation
(0 available);
any
Il36rn mutation
(22 available)
Tg(KRT14-Il1f6)1Hblu mutation
(0 available)
|
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cardiovascular system
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• mice exhibit a dilation of superficial dermal blood vessels
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immune system
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• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
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integument
|
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• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
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• mice exhibit intracorneal and intraepithelial pustules, parakerototic and orthokeratotic hyperkeratinosis, dilated superficial dermal blood vessels, and a mixed dermal inflammatory infiltrate
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• mice exhibit orthokeratotic hyperkeratinosis
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• mice exhibit parakeratotic hyperkeratinosis
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• mice have regions of thick and scaly skin
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• mice have regions of thick and scaly skin
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Analysis Tools