All Phenotypes Ntsr1<tm2Dgen> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:126020 )

• mice do not exhibit a decrease in coordination following treatment with neurotensin 2 unlike wild-type mice

• mice fail to exhibit an increase in latency during a hot plate test following treatment with neurotensin or neurotensin 2 unlike wild-type mice

digestive/alimentary system

intestinal hypoperistalsis ( J:126020 )

• mice do not exhibit a decrease in colonic propulsion following treatment with neurotensin 2 unlike wild-type mice

• however, mice are still susceptible to clonidine induced hypoperistalsis

homeostasis/metabolism

decreased body temperature ( J:126020 )

• following injection of 1 ug neurotensin or 1 mg/kg neurotensin 2, mice fail to exhibit a hypothermic response as wild-type mice do

muscle

intestinal hypoperistalsis ( J:126020 )

• mice do not exhibit a decrease in colonic propulsion following treatment with neurotensin 2 unlike wild-type mice

• however, mice are still susceptible to clonidine induced hypoperistalsis

Allelic Composition	Ntsr1^tm2Dgen/Ntsr1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntsr1^tm2Dgen mutation (0 available); any Ntsr1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestinal hypoperistalsis ( J:126020 )

• mice do not exhibit an intermediate decrease in colonic propulsion following treatment with neurotensin 2 compared to wild-type and homozygous mice

• however, mice are still susceptible to clonidine induced hypoperistalsis

muscle

intestinal hypoperistalsis ( J:126020 )

• mice do not exhibit an intermediate decrease in colonic propulsion following treatment with neurotensin 2 compared to wild-type and homozygous mice

• however, mice are still susceptible to clonidine induced hypoperistalsis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23