Analysis Tools
mortality/aging
|
• 2- to 10-fold less mice survive than wild-type controls when infected intranasaly with P. aeruginosa
|
immune system
|
• about 60% less neutrophils in the lungs of mutant mice 24 hours after infection with P. aeruginosa
|
|
• about a 2-fold increase in apoptotic neutrophils occurs in the lungs of mutant mice 24 hours after infection with P. aeruginosa
• increased apoptosis leads to more than 2-fold increases in levels of neutrophil fragments and myeloperoxidase in lung fluid
• there is about a 3-fold increase in both apoptosis and necrosis of neutrophils when cultured in vitro for 24 hours
|
|
• neutrophil numbers are comparable to wild-type when inflammation is driven by LPS
|
|
• circulating levels of CSF3 (G-CSF) are almost 2 times higher in mutant mice 24 hours after infection with P. aeruginosa
|
|
• about a 3-fold increase in CXCL-1 (KC) levels found in bronchoalveolar fluid of mutant mice 24 hours after infection with P. aeruginosa
|
|
• about a 5-fold increase in IL-1beta levels found in bronchoalveolar fluid of mutant mice 24 hours after infection with P. aeruginosa
|
|
• about a 2.5-fold increase in TNF levels found in bronchoalveolar fluid of mutant mice 24 hours after infection with P. aeruginosa
|
|
• numerous bacterial colonies and large areas of alveolar exudates are present in the lungs 24 hours after P. aeruginosa infection
|
|
• median bacterial count in the lungs is 3 to 5 log units higher than wild-type controls 24 hours after infection with two different strains of P. aeruginosa
|
|
• 2- to 10-fold less mice survive than wild-type controls when infected intranasaly with P. aeruginosa
|
|
• 2 log units of P. aeruginosa bacteria are in spleen of mice 24 hours after infection compared to none in wild-type controls
|
respiratory system
|
• numerous bacterial colonies and large areas of alveolar exudates are present in the lungs 24 hours after P. aeruginosa infection
|
|
• 24 hours after P. aeruginosa infection, homozygotes display a significant reduction in pulmonary surfactant protein-D levels due to increased proteolytic activity
|
hematopoietic system
|
• about 60% less neutrophils in the lungs of mutant mice 24 hours after infection with P. aeruginosa
|
|
• about a 2-fold increase in apoptotic neutrophils occurs in the lungs of mutant mice 24 hours after infection with P. aeruginosa
• increased apoptosis leads to more than 2-fold increases in levels of neutrophil fragments and myeloperoxidase in lung fluid
• there is about a 3-fold increase in both apoptosis and necrosis of neutrophils when cultured in vitro for 24 hours
|
|
• neutrophil numbers are comparable to wild-type when inflammation is driven by LPS
|
homeostasis/metabolism
|
• circulating levels of CSF3 (G-CSF) are almost 2 times higher in mutant mice 24 hours after infection with P. aeruginosa
|
cellular
|
• neutrophil numbers are comparable to wild-type when inflammation is driven by LPS
|
