Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkrstm1Nemz mutation
(1 available);
any
Igkrs mutation
(1 available)
Tg(UBC-scFv)2Nemz mutation
(1 available)
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immune system
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• there is slight increase in autoreactive B cells expressing kappa chain that escape selection in the bone marrow
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• there are fewer B cells expressing lambda chain in the bone marrow
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• there are fewer B cells expressing lambda chain in the spleen
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hematopoietic system
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• there is slight increase in autoreactive B cells expressing kappa chain that escape selection in the bone marrow
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• there are fewer B cells expressing lambda chain in the bone marrow
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• there are fewer B cells expressing lambda chain in the spleen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(UBC-scFv)2Nemz mutation
(1 available)
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immune system
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• B220+ cells fail to express kappa light chain
• immature B cells expressing kappa light chain are forced to undergo receptor editing
• kappa light chain is detected in cytoplasm
• proliferation is not increased
• levels of lambda V and J excision products exhibit a three fold increase in bone marrow and spleen cells
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• B220+ peripheral B cell numbers are reduced by approximately 50%
• B220+ fraction of spleen cells is reduced 60%
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• percentage of lambda positive B cells in peripheral lymphoid tissues is increased seven fold relative to non-transgenic mice
• kappa positive B cells are absent from peripheral lymphoid tissues
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• kappa positive B1-b cells are absent in the peritoneal cavity
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• total number of splenic cells is reduced 80% as compared to control
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• total number of splenic cells is reduced 80% as compared to control
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• kappa serum IgM and IgG2a/b are decreased, however, lambda serum IgM and IgG2a/b are increased
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• mice are tolerized to anti-kappa light chain resulting in the absence of kappa expressing B cells
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hematopoietic system
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• B220+ cells fail to express kappa light chain
• immature B cells expressing kappa light chain are forced to undergo receptor editing
• kappa light chain is detected in cytoplasm
• proliferation is not increased
• levels of lambda V and J excision products exhibit a three fold increase in bone marrow and spleen cells
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• B220+ peripheral B cell numbers are reduced by approximately 50%
• B220+ fraction of spleen cells is reduced 60%
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• percentage of lambda positive B cells in peripheral lymphoid tissues is increased seven fold relative to non-transgenic mice
• kappa positive B cells are absent from peripheral lymphoid tissues
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• kappa positive B1-b cells are absent in the peritoneal cavity
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• total number of splenic cells is reduced 80% as compared to control
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• total number of splenic cells is reduced 80% as compared to control
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• kappa serum IgM and IgG2a/b are decreased, however, lambda serum IgM and IgG2a/b are increased
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Analysis Tools