All Phenotypes Tapt1<L5Jcs1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tapt1^L5Jcs1
lethal 5 John C Schimenti 1
MGI:3760260

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tapt1^L5Jcs1/Tapt1^L5Jcs1	involves: 101/H * C3H/HeH * C3HeB/FeJ * C57BL/6J	MGI:3760265
cx2	Qdpr^tm1Jcs/Qdpr⁺ Tapt1^L5Jcs1/Tapt1⁺	involves: 101/H * 129S4/SvJae * C3H/HeH * C3HeB/FeJ * C57BL/6J	MGI:3760266

Allelic Composition	Tapt1^L5Jcs1/Tapt1^L5Jcs1
Genetic Background	involves: 101/H * C3H/HeH * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tapt1^L5Jcs1 mutation (0 available); any Tapt1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:100332 )

• mice die around birth

skeleton

abnormal skeleton morphology ( J:100332 )

• beginning between E18.5 and day 1, mice exhibit skeletal and bone defects

abnormal sternocostal joint morphology ( J:100332 , J:125425 )

• unlike in wild-type mice, the eighth rib is attached to the sixth sternebra (J:100332)

• unlike in wild-type mice, the eighth rib is attached to the sixth sternebra (J:125425)

split xiphoid process ( J:125425 )

• in most mice the xiphoid process overgrown and splayed

thoracic vertebral transformation ( J:125425 )

• 10 of 13 mice exhibit a T8 to T7 transformation compared to only 1 of 30 mice heterozygous for this allele or Rw

lumbar vertebral transformation ( J:125425 )

• 6 of 13 mice exhibit a L1 to T14 transformation compared to only 1 of 30 mice heterozygous for this allele or Rw

Allelic Composition	Qdpr^tm1Jcs/Qdpr⁺ Tapt1^L5Jcs1/Tapt1⁺
Genetic Background	involves: 101/H * 129S4/SvJae * C3H/HeH * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qdpr^tm1Jcs mutation (0 available); any Qdpr mutation (17 available)
Tapt1^L5Jcs1 mutation (0 available); any Tapt1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternocostal joint morphology ( J:125425 )

• some mice exhibit a fusion of T8 to the sternum

split xiphoid process ( J:125425 )

• some mice exhibit the a splayed xiphoid process

lumbar vertebral transformation ( J:125425 )

• some mice exhibit a posterior to anterior transformation of L1

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