All Phenotypes F10<tm2Ccmt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

F10^tm2Ccmt
targeted mutation 2, Katherine A High
MGI:3760000

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F10^tm2Ccmt/F10^tm2Ccmt	involves: 129P2/OlaHsd * C57BL/6	MGI:3841067
ht2	F10^tm1Ccmt/F10^tm2Ccmt	involves: 129P2/OlaHsd * C57BL/6	MGI:3841065

Allelic Composition	F10^tm2Ccmt/F10^tm2Ccmt
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F10^tm2Ccmt mutation (0 available); any F10 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:145092 )

N	• unlike mice homozygous for F10 null alleles, survival for the first month of life is 100% and 80% at 18 months

cardiovascular system

increased heart iron level ( J:145092 )

• at 10 months, mice exhibit iron depositions in the myocardium accompanied by fibrosis unlike in wild-type mice

cardiac fibrosis ( J:145092 )

• at 10 months, mice exhibit fibrosis that accompanies iron deposits unlike wild-type mice

homeostasis/metabolism

increased heart iron level ( J:145092 )

• at 10 months, mice exhibit iron depositions in the myocardium accompanied by fibrosis unlike in wild-type mice

Allelic Composition	F10^tm1Ccmt/F10^tm2Ccmt
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F10^tm1Ccmt mutation (0 available); any F10 mutation (28 available)
F10^tm2Ccmt mutation (0 available); any F10 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased litter size ( J:145092 )

• female mice produce fewer F10^tm1Ccmt homozygous pups than female F10^tm1Ccmt heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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