Phenotypes associated with this allele

• Allele Symbol: Gab1^tm4Wbm
• Allele Name: targeted mutation 4, Walter Birchmeier
• Allele ID: MGI:3759866
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gab1^tm4Wbm/Gab1^tm4Wbm	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	MGI:3759966

Genotype
MGI:3759966

hm1

• Allelic Composition: Gab1^tm4Wbm/Gab1^tm4Wbm
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gab1^tm4Wbm/Gab1^tm4Wbm mice have open eyelids at birth and keratinocytes show impaired wound closure in vitro

homeostasis/metabolism

impaired wound healing ( J:125303 )

• in a scratch-wound closure assay, wound closure is impaired in response to TGF-alpha

• however, wound healing in the presence of hepatocyte growth factor and scatter factor (HGF/SF)

vision/eye

eyelids open at birth ( J:125303 )

• although Mendelian ratios of mice are born, 14 of 22 mice are born with eyelids open