About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grb10GT(XC302)Byg
gene trap XC302, BayGenomics
MGI:3759253
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grb10GT(XC302)Byg/Grb10GT(XC302)Byg involves: 129P2/OlaHsd MGI:7294429
hm2
 		Grb10GT(XC302)Byg/Grb10GT(XC302)Byg involves: 129P2/OlaHsd * Black Swiss * C57BL/6 MGI:3759255
cx3
 		Grb10GT(XC302)Byg/Grb10GT(XC302)Byg
Nedd4Gt(XA209)Byg/Nedd4Gt(XA209)Byg 		involves: 129P2/OlaHsd MGI:7294428
cx4
 		Grb10GT(XC302)Byg/Grb10GT(XC302)Byg
Nedd4Gt(XA209)Byg/Nedd4+ 		involves: 129P2/OlaHsd MGI:7294430
cx5
 		Grb10GT(XC302)Byg/Grb10+
Nedd4Gt(XA209)Byg/Nedd4Gt(XA209)Byg 		involves: 129P2/OlaHsd MGI:7294432


Genotype
MGI:7294429
hm1
Allelic
Composition		 Grb10GT(XC302)Byg/Grb10GT(XC302)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10GT(XC302)Byg mutation (0 available); any Grb10 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3759255
hm2
Allelic
Composition		 Grb10GT(XC302)Byg/Grb10GT(XC302)Byg
Genetic
Background		 involves: 129P2/OlaHsd * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10GT(XC302)Byg mutation (0 available); any Grb10 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased pancreas weight ( J:125128 )
• pancreas weight is increased relative to in wild-type mice
increased lean body mass ( J:125128 )
• increase in lean mass is proportional to the increase in body weight
increased body weight ( J:125128 )
• mice exhibit increased body weight and size with an increase in both fat and lean mass in males and females relative to wild-type mice
increased lung weight ( J:125128 )

homeostasis/metabolism
increased insulin sensitivity ( J:125128 )
• insulin sensitivity in muscles was higher than in wild-type mice
• insulin resistance induced by a high fat diet is blunted compared to in wild-type mice
• however, liver insulin sensitivity is normal

endocrine/exocrine glands
increased pancreas weight ( J:125128 )
• pancreas weight is increased relative to in wild-type mice

muscle

respiratory system




Genotype
MGI:7294428
cx3
Allelic
Composition		 Grb10GT(XC302)Byg/Grb10GT(XC302)Byg
Nedd4Gt(XA209)Byg/Nedd4Gt(XA209)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10GT(XC302)Byg mutation (0 available); any Grb10 mutation (53 available)
Nedd4Gt(XA209)Byg mutation (0 available); any Nedd4 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7294430
cx4
Allelic
Composition		 Grb10GT(XC302)Byg/Grb10GT(XC302)Byg
Nedd4Gt(XA209)Byg/Nedd4+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10GT(XC302)Byg mutation (0 available); any Grb10 mutation (53 available)
Nedd4Gt(XA209)Byg mutation (0 available); any Nedd4 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7294432
cx5
Allelic
Composition		 Grb10GT(XC302)Byg/Grb10+
Nedd4Gt(XA209)Byg/Nedd4Gt(XA209)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10GT(XC302)Byg mutation (0 available); any Grb10 mutation (53 available)
Nedd4Gt(XA209)Byg mutation (0 available); any Nedd4 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:207675 )
• until weaning when Grb10GT(XC302)Byg is inherited maternally

mortality/aging
preweaning lethality, incomplete penetrance ( J:207675 )
• when fewer than expected mice are produced no mice are produced when Grb10GT(XC302)Byg is inherited paternally
• however, mice are produced with Grb10GT(XC302)Byg is inherited maternally




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory