Phenotypes associated with this allele

• Allele Symbol: Steap3^fred
• Allele Name: fragile-red
• Allele ID: MGI:3758911
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Steap3^fred/Steap3^fred	C57BL/6-Steap3^fred	MGI:3833932

Genotype
MGI:3833932

hm1

• Allelic Composition: Steap3^fred/Steap3^fred
• Genetic Background: C57BL/6-Steap3^fred

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:145194 )

N • unlike red cells, leukocyte and platelet numbers are similar to controls

enlarged spleen ( J:145194 )

hypochromic microcytic anemia ( J:145194 )

decreased hemoglobin content ( J:145194 )

• reduced mean hemoglobin level

anisopoikilocytosis ( J:145194 )

leptocytosis ( J:145194 )

• target cells are present

polychromatophilia ( J:145194 )

• polychromasia

reticulocytosis ( J:145194 )

abnormal erythrocyte physiology ( J:145194 )

• two fold reduction in ferrireductase activity in whole blood cells

homeostasis/metabolism

decreased circulating copper level ( J:145194 )

• decreased serum cupric levels

increased liver copper level ( J:145194 )

abnormal iron homeostasis ( J:145194 )

• total iron binding capacity is elevated almost 2 fold and saturation is similar to controls

increased liver iron level ( J:145194 )

• significantly increased in females

cardiovascular system

enlarged heart ( J:145194 )

liver/biliary system

increased liver copper level ( J:145194 )

increased liver iron level ( J:145194 )

• significantly increased in females

reproductive system

reproductive system phenotype ( J:145194 )

N • despite anemia mice are able to breed normally

immune system

enlarged spleen ( J:145194 )

growth/size/body

enlarged heart ( J:145194 )

enlarged spleen ( J:145194 )