All Phenotypes Inhba<tm3Zuk> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inhba^tm3Zuk/Inhba^tm3Zuk	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3758886
cn2	Inhba^tm1Zuk/Inhba^tm3Zuk Inhbb^tm1Jae/Inhbb^tm1Jae Amhr2^tm3(cre)Bhr/Amhr2⁺	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:3758888
cn3	Amhr2^tm3(cre)Bhr/Amhr2⁺ Inhba^tm1Zuk/Inhba^tm3Zuk	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3758887
cn4	Inhba^tm1Zuk/Inhba^tm3Zuk Tg(EIIa-cre)C5379Lmgd/?	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:3758885
cx5	Inhba^tm1Zuk/Inhba^tm3Zuk Inhbb^tm1Jae/Inhbb^tm1Jae	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:3758893

Allelic Composition	Inhba^tm3Zuk/Inhba^tm3Zuk
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhba^tm3Zuk mutation (1 available); any Inhba mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:125354 )

• mice are viable, fertile and obtained in expected Mendelian frequency

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

absent oocytes ( J:125354 )

• 2 of 4 females produce no oocytes upon superovulation

• however, there is no difference in the number of oocytes superovulated in the remaining 2 mice

reproductive system

absent oocytes ( J:125354 )

• 2 of 4 females produce no oocytes upon superovulation

• however, there is no difference in the number of oocytes superovulated in the remaining 2 mice

increased corpora lutea number ( J:125354 )

• at 6 weeks, 8 to 11 weeks, and 3 months of age, the number of corpus luteums is increased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

abnormal ovarian follicle morphology ( J:125354 )

• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

• at 8 months, follicles with lutenizing granulosa cells and multiple fluid-filled or hemorrhagic cysts are present

abnormal tertiary ovarian follicle morphology ( J:125354 )

• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

ovarian follicular cyst ( J:125354 )

• at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

• by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

female infertility ( J:125354 )

• females are infertile

growth/size/body

ovarian follicular cyst ( J:125354 )

• at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

• by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

homeostasis/metabolism

increased follicle stimulating hormone level ( J:125354 )

endocrine/exocrine glands

increased corpora lutea number ( J:125354 )

• at 6 weeks, 8 to 11 weeks, and 3 months of age, the number of corpus luteums is increased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

abnormal ovarian follicle morphology ( J:125354 )

• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

• at 8 months, follicles with lutenizing granulosa cells and multiple fluid-filled or hemorrhagic cysts are present

abnormal tertiary ovarian follicle morphology ( J:125354 )

• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

ovarian follicular cyst ( J:125354 )

• at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

• by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

Allelic Composition	Amhr2^tm3(cre)Bhr/Amhr2⁺ Inhba^tm1Zuk/Inhba^tm3Zuk
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (27 available)
Inhba^tm1Zuk mutation (2 available); any Inhba mutation (31 available)
Inhba^tm3Zuk mutation (1 available); any Inhba mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased corpora lutea number ( J:125354 )

• at 8 months of age, the number of corpus luteums is increased compared to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

polyovular ovarian follicle ( J:125354 )

• one follicle containing two oocytes at 3 months of age

reduced female fertility ( J:125354 )

• the number of litters produced by females is reduced 43% (0.51+/-0.05 litters per month compared 0.89+/-0.04 litters per month in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

• however, there is no difference in the number of oocytes produced upon superovulation compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

decreased litter size ( J:125354 )

• the number of pups per litter is decreased 33% relative (5.19+/-0.65 pups per litter compared to 7.78+/-0.48 pups per litter in wild-type mice)

endocrine/exocrine glands

increased corpora lutea number ( J:125354 )

• at 8 months of age, the number of corpus luteums is increased compared to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

polyovular ovarian follicle ( J:125354 )

• one follicle containing two oocytes at 3 months of age

Allelic Composition	Inhba^tm1Zuk/Inhba^tm3Zuk Tg(EIIa-cre)C5379Lmgd/?
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhba^tm1Zuk mutation (2 available); any Inhba mutation (31 available)
Inhba^tm3Zuk mutation (1 available); any Inhba mutation (31 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:125354 )

• mice die shortly after birth similar to Inhba^tm1Zuk homozygotes

Allelic Composition	Inhba^tm1Zuk/Inhba^tm3Zuk Inhbb^tm1Jae/Inhbb^tm1Jae
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:125354 )

• 3 of 5 females are infertile

reduced female fertility ( J:125354 )

• the number of litters produced by females is reduced 43% (0.10+/-0.07 litters per month compared 0.89+/-0.04 litters per month in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

• however, there is no difference in the number of oocytes produced upon superovulation compared to Inhba^tm1Zuk/Inhba^tm3Zuk females

decreased litter size ( J:125354 )

• the number of pups per litter is decreased 33% relative (1.00+/-0.63 pups per litter compared to 7.78+/-0.48 pups per litter in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

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