Phenotypes associated with this allele

• Allele Symbol: Tg(Fabp4-Aebp1)1Hsro
• Allele Name: transgene insertion 1, Hyo-Sung Ro
• Allele ID: MGI:3758185
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Fabp4-Aebp1)1Hsro/?	involves: FVB	MGI:3758326

Genotype
MGI:3758326

tg1

• Allelic Composition: Tg(Fabp4-Aebp1)1Hsro/?
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:125334 )

• during 7 months on a high fat diet, 39% of female mice die (the earliest at 13 weeks, 2 at 14 weeks, 1 each at 15, 19, 20, 21 and 27 weeks, and the last at 30 weeks)

premature death ( J:125334 )

• 21% (12 of 56) female mice die on a regular diet

adipose tissue

increased white adipose tissue amount ( J:125334 )

• after 7 months on a high fat diet, the amount of white adipose tissue to body weight in females is 1.5-fold greater than in wild-type mice

abnormal fat cell morphology ( J:125334 )

• the average adipocyte cell size in female mice on a high fat diet (0.191 ug/cell) is smaller than in wild-type mice (0.215 ug/cell)

• fat cell density is increased 1.1-fold in female mice fed a high fat diet compared to wild-type mice due to hyperplasia

homeostasis/metabolism

increased circulating insulin level ( J:125334 )

• at the end of 7 months, insulin levels in female mice on a high fat diet are increased 2-fold compared to in wild-type mice

increased circulating leptin level ( J:125334 )

• leptin levels are increased by 2.4-fold in female mice fed a high fat diet relative to wild-type mice

growth/size/body

increased body weight ( J:125334 )

• at 32 weeks on a high fat diet, female mice exhibit a 1.6-fold increase in mass relative to wild-type mice

• from 21 to 25 weeks, relative mass gained per food consumed by female mice is greater than in wild-type mice

• a second group of female fed a high fat diet exhibit a 1.3-fold increase in mass at 32 weeks while eating 1.3-fold more food than wild-type mice

obese ( J:125334 )

• after 7 months on a high fat diet, surviving female mice are obese

increased susceptibility to weight gain ( J:125334 )

• at 21 weeks of age on a high fat diet, female weight gain is increased relative to that observed in wild-type mice

cardiovascular system

atherosclerotic lesions ( J:125334 )

• female mice develop atherosclerotic lesions in the root of the aorta on a high fat diet

behavior/neurological

increased food intake ( J:125334 )

• at 20 and 21 weeks on a high fat diet, food intake is increased relative to that of wild-type mice

• at 32 weeks, female mice eat 1.3-fold more food than wild-type mice