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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr158tm1(Igh)Xu
targeted mutation 1, Yang Xu
MGI:3757685
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr158tm1(Igh)Xu/Rr158tm1(Igh)Xu Not Specified MGI:3758450
cx2
 		Igkctm1(IGKC)Mnz/Igkc+
Rr158tm1(Igh)Xu/Rr158+ 		Not Specified MGI:3758451


Genotype
MGI:3758450
hm1
Allelic
Composition		 Rr158tm1(Igh)Xu/Rr158tm1(Igh)Xu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system morphology ( J:124407 )
• Igk rearrangement in pre-B cells is less efficient than in wild-type cells due to limited access to variable region segments
decreased B cell number ( J:124407 )
• total B cell number in the spleen and bone marrow is decreased by about 50% compared to in wild-type mice
• the number of kappa+ splenic B cells is reduced lowering the ratio of kappa to lambda B cells to 6:1 compared to 20:1 in wild-type mice
decreased immature B cell number ( J:124407 )
• the number of immature B cells (B220+IgM+IgDlow) is decreased relative to in wild-type mice
increased pre-B cell number ( J:124407 )
• the number of pre-B cells (B220+CD43-IgM-) is increased relative to in wild-type mice

hematopoietic system
decreased B cell number ( J:124407 )
• total B cell number in the spleen and bone marrow is decreased by about 50% compared to in wild-type mice
• the number of kappa+ splenic B cells is reduced lowering the ratio of kappa to lambda B cells to 6:1 compared to 20:1 in wild-type mice
decreased immature B cell number ( J:124407 )
• the number of immature B cells (B220+IgM+IgDlow) is decreased relative to in wild-type mice
increased pre-B cell number ( J:124407 )
• the number of pre-B cells (B220+CD43-IgM-) is increased relative to in wild-type mice




Genotype
MGI:3758451
cx2
Allelic
Composition		 Igkctm1(IGKC)Mnz/Igkc+
Rr158tm1(Igh)Xu/Rr158+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1(IGKC)Mnz mutation (2 available); any Igkc mutation (9 available)
Rr158tm1(Igh)Xu mutation (0 available); any Rr158 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system morphology ( J:124407 )
• the efficiency of rearrangement of the Igk-Eiktm1(Igh)Xu allele is lower than that of the wild-type allele
decreased B cell number ( J:124407 )
• the percent of mouse immunoglobin kappa+ B cells is reduced with the ratio of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells of about 6:1 compared to equal number of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells when the wild-type Igk allele is present instead of Igk-Eiktm1(Igh)Xu

hematopoietic system
decreased B cell number ( J:124407 )
• the percent of mouse immunoglobin kappa+ B cells is reduced with the ratio of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells of about 6:1 compared to equal number of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells when the wild-type Igk allele is present instead of Igk-Eiktm1(Igh)Xu




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory