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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm2.1Hws
targeted mutation 2.1, Harry W Schroeder Jr
MGI:3757674
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm2.1Hws/Ightm2.1Hws involves: BALB/c MGI:3822282
hm2
 		Ightm2.1Hws/Ightm2.1Hws involves: BALB/c * C57BL/6NCrl * DBA/2NCrl MGI:3758613


Genotype
MGI:3822282
hm1
Allelic
Composition		 Ightm2.1Hws/Ightm2.1Hws
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2.1Hws mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased immature B cell number ( J:142069 )
• there is over a 30% decrease in the number of immature B cells (ie. fraction E cells) found in the bone marrow
decreased transitional stage B cell number ( J:142069 )
• there is about a 40% decrease in the number of transitional T3(A) B cells (i.e. "anergic" B cells) found in the spleen
increased early pro-B cell number ( J:142069 )
• there is a 60% increase in the number of early pro-B cells (i.e. fraction B cells) found in the bone marrow of mutant mice
decreased late pro-B cell number ( J:142069 )
• there is about a 40% decrease in the number of late pro-B cells (i.e. fraction D cells) compared to controls
decreased mature B cell number ( J:142069 )
• there is over a 40% decrease in the number of mature recirculating B cells found in the bone marrow
decreased B-1a cell number ( J:142069 )
• there is a over a 40% decrease in the number of B-1a B cells found in the peritoneal cavity
decreased follicular B cell number ( J:142069 )
• there is over a 40% decrease in the number of follicular B cells found in the spleen
increased marginal zone B cell number ( J:142069 )
• there is about a 40% increase in the number of marginal zone B cells found in the spleen
decreased IgM level ( J:142069 )
• mean antigen specific IgM levels are one-tenth of that observed in wild-type controls seven days after immunization with the T cell-independent antigen DEX
increased anti-nuclear antigen antibody level ( J:142069 )
• sera from 2 of 15 mice demonstrated ANA activity that was above background

hematopoietic system
decreased immature B cell number ( J:142069 )
• there is over a 30% decrease in the number of immature B cells (ie. fraction E cells) found in the bone marrow
decreased transitional stage B cell number ( J:142069 )
• there is about a 40% decrease in the number of transitional T3(A) B cells (i.e. "anergic" B cells) found in the spleen
increased early pro-B cell number ( J:142069 )
• there is a 60% increase in the number of early pro-B cells (i.e. fraction B cells) found in the bone marrow of mutant mice
decreased late pro-B cell number ( J:142069 )
• there is about a 40% decrease in the number of late pro-B cells (i.e. fraction D cells) compared to controls
decreased mature B cell number ( J:142069 )
• there is over a 40% decrease in the number of mature recirculating B cells found in the bone marrow
decreased B-1a cell number ( J:142069 )
• there is a over a 40% decrease in the number of B-1a B cells found in the peritoneal cavity
decreased follicular B cell number ( J:142069 )
• there is over a 40% decrease in the number of follicular B cells found in the spleen
increased marginal zone B cell number ( J:142069 )
• there is about a 40% increase in the number of marginal zone B cells found in the spleen
decreased IgM level ( J:142069 )
• mean antigen specific IgM levels are one-tenth of that observed in wild-type controls seven days after immunization with the T cell-independent antigen DEX




Genotype
MGI:3758613
hm2
Allelic
Composition		 Ightm2.1Hws/Ightm2.1Hws
Genetic
Background		 involves: BALB/c * C57BL/6NCrl * DBA/2NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2.1Hws mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased marginal zone B cell number ( J:124421 )
• the number of marginal zone B cells is increased by one third relative to in wild-type mice
decreased B cell number ( J:124421 )
• total B cell number is reduced relative to wild-type mice
• the absolute number of CD19+ cells in the bone marrow, spleen and peritoneal cavity is two thirds of that observed in wild-type mice
decreased transitional stage B cell number ( J:124421 )
• the number of T3 B cells is reduced by half compared to in wild-type mice
decreased B-1a cell number ( J:124421 )
• the absolute number of B-1a B cells in the peritoneal cavity is half of that in wild-type mice
decreased B-1b cell number ( J:124421 )
• the absolute number of B-1b B cells in the peritoneal cavity is a quarter of that in wild-type mice
decreased follicular B cell number ( J:124421 )
• mature follicular B cells is reduced by half compared to in wild-type mice
decreased pre-B cell number ( J:124421 )
• the number of late pre-B cells is decreased by 30% relative to in wild-type mice
abnormal humoral immune response ( J:124421 )
• following exposure to NP-CGG, the anti-NP IgG response is diminished 3-fold relative to in wild-type mice
• following exposure to tetanus toxin (TT), the anti-TT IgG response is decreased 4-fold relative to in wild-type micefollowing exposure to tetanus toxin (TT), the anti-TT IgG response is decreased 4-fold relative to in wild-type mice
• however, the IgM response to TT is normal
• following intravenous alpha-1,3 dextran (DEX) challenge, IgM and Ig-lambda levels are lower than in similarly treated wild-type mice
decreased IgM level ( J:124421 )
• following intravenous alpha-1,3 dextran (DEX) challenge, IgM and Ig-lambda levels are lower than in similarly treated wild-type mice

hematopoietic system
increased marginal zone B cell number ( J:124421 )
• the number of marginal zone B cells is increased by one third relative to in wild-type mice
decreased B cell number ( J:124421 )
• total B cell number is reduced relative to wild-type mice
• the absolute number of CD19+ cells in the bone marrow, spleen and peritoneal cavity is two thirds of that observed in wild-type mice
decreased transitional stage B cell number ( J:124421 )
• the number of T3 B cells is reduced by half compared to in wild-type mice
decreased B-1a cell number ( J:124421 )
• the absolute number of B-1a B cells in the peritoneal cavity is half of that in wild-type mice
decreased B-1b cell number ( J:124421 )
• the absolute number of B-1b B cells in the peritoneal cavity is a quarter of that in wild-type mice
decreased follicular B cell number ( J:124421 )
• mature follicular B cells is reduced by half compared to in wild-type mice
decreased pre-B cell number ( J:124421 )
• the number of late pre-B cells is decreased by 30% relative to in wild-type mice
decreased IgM level ( J:124421 )
• following intravenous alpha-1,3 dextran (DEX) challenge, IgM and Ig-lambda levels are lower than in similarly treated wild-type mice




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05/07/2024
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