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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fosl2tm2.1Wag
targeted mutation 2.1, Erwin F Wagner
MGI:3757560
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fosl2tm2.1Wag/Fosl2tm2.1Wag involves: 129P2/OlaHsd MGI:3757561
hm2
 		Fosl2tm2.1Wag/Fosl2tm2.1Wag involves: 129P2/OlaHsd * C57BL/6 MGI:4834994


Genotype
MGI:3757561
hm1
Allelic
Composition		 Fosl2tm2.1Wag/Fosl2tm2.1Wag
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl2tm2.1Wag mutation (0 available); any Fosl2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:125028 )
• die within a week of birth

growth/size/body
decreased body size ( J:125028 )
• mice become runted after birth
postnatal growth retardation ( J:125028 )




Genotype
MGI:4834994
hm2
Allelic
Composition		 Fosl2tm2.1Wag/Fosl2tm2.1Wag
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl2tm2.1Wag mutation (0 available); any Fosl2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast morphology ( J:137646 )
• oteoclast number and size are increased compared to in wild-type mice
abnormal osteoclast differentiation ( J:137646 )
• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells
abnormal osteoclast physiology ( J:137646 )
• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells
• osteoclasts are hypoxic unlike in wild-type mice

homeostasis/metabolism
hypoxia ( J:137646 )
• osteoclasts are hypoxic unlike in wild-type mice

immune system
abnormal osteoclast morphology ( J:137646 )
• oteoclast number and size are increased compared to in wild-type mice
abnormal osteoclast differentiation ( J:137646 )
• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells
abnormal osteoclast physiology ( J:137646 )
• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells
• osteoclasts are hypoxic unlike in wild-type mice

hematopoietic system
abnormal osteoclast morphology ( J:137646 )
• oteoclast number and size are increased compared to in wild-type mice
abnormal osteoclast differentiation ( J:137646 )
• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells
abnormal osteoclast physiology ( J:137646 )
• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells
• osteoclasts are hypoxic unlike in wild-type mice

cellular
abnormal osteoclast differentiation ( J:137646 )
• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory