Phenotypes associated with this allele

• Allele Symbol: Fosl2^tm2.1Wag
• Allele Name: targeted mutation 2.1, Erwin F Wagner
• Allele ID: MGI:3757560
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fosl2^tm2.1Wag/Fosl2^tm2.1Wag	involves: 129P2/OlaHsd	MGI:3757561
hm2	Fosl2^tm2.1Wag/Fosl2^tm2.1Wag	involves: 129P2/OlaHsd * C57BL/6	MGI:4834994

Genotype
MGI:3757561

hm1

• Allelic Composition: Fosl2^tm2.1Wag/Fosl2^tm2.1Wag
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:125028 )

• die within a week of birth

growth/size/body

decreased body size ( J:125028 )

• mice become runted after birth

postnatal growth retardation ( J:125028 )

Genotype
MGI:4834994

hm2

• Allelic Composition: Fosl2^tm2.1Wag/Fosl2^tm2.1Wag
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

skeleton

abnormal osteoclast morphology ( J:137646 )

• oteoclast number and size are increased compared to in wild-type mice

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells

increased osteoclast cell number ( J:137646 )

abnormal osteoclast physiology ( J:137646 )

• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells

• osteoclasts are hypoxic unlike in wild-type mice

decreased bone mineral density ( J:137646 )

• at birth

increased bone resorption ( J:137646 )

homeostasis/metabolism

hypoxia ( J:137646 )

• osteoclasts are hypoxic unlike in wild-type mice

immune system

abnormal osteoclast morphology ( J:137646 )

• oteoclast number and size are increased compared to in wild-type mice

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells

increased osteoclast cell number ( J:137646 )

abnormal osteoclast physiology ( J:137646 )

• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells

• osteoclasts are hypoxic unlike in wild-type mice

hematopoietic system

abnormal osteoclast morphology ( J:137646 )

• oteoclast number and size are increased compared to in wild-type mice

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells

increased osteoclast cell number ( J:137646 )

abnormal osteoclast physiology ( J:137646 )

• osteoclast progenitors exhibit increased apoptosis compared with wild-type cells

• osteoclasts are hypoxic unlike in wild-type mice

cellular

abnormal osteoclast differentiation ( J:137646 )

• fetal liver derived osteoclast progenitors fail to differentiate in vitro unlike similarly treated wild-type cells